[发明专利]一个与心脏发育相关的人类新基因ZNF382无效
| 申请号： | 02114359.5 | 申请日： | 2002-08-26 |
| 公开（公告）号： | CN1439719A | 公开（公告）日： | 2003-09-03 |
| 发明（设计）人： | 吴秀山;王跃群;罗开梅;袁婺洲;李永青;朱传炳 | 申请（专利权）人： | 湖南师范大学 |
| 主分类号： | C12N15/12 | 分类号： | C12N15/12;C07H21/04 |
| 代理公司： | 湖南兆弘专利事务所 | 代理人： | 赵洪 |
| 地址： | 410081 湖南省长沙市河西岳*** | 国省代码： | 湖南;43 |
| 权利要求书： | 查看更多 | 说明书： | 查看更多 |
| 摘要： | 一个与心脏发育相关的人类新基因ZNF382涉及锌指蛋白家族的人类基因。本发明与心脏发育相关的人类基因ZNF382，它的cDNA全长2824bp，编码548个氨基酸，约60KD，起始密码子ATG始于核苷酸114，终止密码子TAA在核苷酸1760位置，ZNF382定位于19q13.13，ZNF382mRNA只局限在心脏和骨骼肌表达，而且在心脏的表达水平大大高于在骨骼肌的表达水平，表明ZNF382对心脏的晚期发育和功能发挥起重要作用，可能成为治疗心脏疾病的基因药物。 | ||
| 搜索关键词： | 一个 心脏 发育 相关 人类 基因 znf382 | ||
【主权项】：
1、一个与心脏发育相关的人类新基因ZNF382，其特征在于该人类新基因ZNF382的cDNA核苷酸序列与编码氨基酸序列如下：gactcaccctgggccgggggtgaggcttggactgtttctttttccaaaag50aggagctcaaaagagaaagttcatctagaaatctcaaagccatgtctcag100gatgaactagagt113atgcccttacagggatcagtgtcattcaaggatgtgactgtggac158MetProLeuGlnGlySerValSerPheLysAspValThrValAsp151015ttcacccaggaggagtggcagcaactagaccctgctcagaaggcg203PheThrGlnGluGluTrpGlnGlnLeuAspProAlaGlnLysAla202530ctttacagggatgtgatgttggaaaactattgccacttcgtatct248LeuTyrArgAspValMetLeuGluAsnTyrCysHisPheValSet354045gtggggtttcacatggctaagcctgatatgatccgcaagttggaa293ValGlyPheHisMetAlaLysProAspMetIleArgLysLeuGlu505560caaggagaagagctatggacacagagaatttttccaagttacagc338GlnGlyGluGluLeuTrpThrGlnArgIlePheProSerTyrSer657075tacctagaagaagatgggaaaactgaagatgtcttagtgaagttc383TyrLeuGluGluAspGlyLysThrGluAspValLeuValLysPhe808590aaagaataccaagacaggcattctagacccctcatattcatcaac428LysGluTyrGlnAspArgHisSerArgProLeuIlePheIleAsn95100105cacaaaaaactaattaaggagagaagtaatatttatggtaaaaca473HisLysLysLeuIleLysGluArgSerAsnIleTyrGlyLysThr110115120tttactctaggcaagaaccgtattacaatactatgtgaatataaa518PheThrLeuGlyLysAsnArgIleThrIleLeuCysGluTyrLys125130135cctgatggaaaagtttLgaaaaatatttcagaactagtcattaga563ProAspGlyLysValLeuLysAsnIleSerGluLeuValIleArg140145150aatataagccccataaaagagaagtttggtgacagtactggatgg608AsnIleSerProIleLysGluLysPheGlyAspSerThrGlyTrp155160165gagaaatcactcctcaataccaagcatgagaaaattcatcctgca653GluLysSerLeuLeuAsnThrLysHisGluLysIleHisProAla170175180gtgaatctccataaacaaacagaaagagttctcagtggtaaacag698ValAsnLeuHisLysGlnThrGluArgValLeuSerGlyLysGln185190195gagcttattcagcatcagaaggttcaagctccagagcaaccattt743GluLeuIleGlnHisGlnLysValGlnAlaProGluGlnProPhe200205210gaccataatgaatgtgaaaaatccttcctgatgaaaggaatgcta788AspHisAsnGluCysGluLysSerPheLeuMetLysGlyMetLeu215220225tttacacatactagagctcacagaggagaaagaacctttgaatac833PheThrHisThrArgAlaHisArgGlyGluArgThrPheGluTyr230235240aataaagatggaattgccttcatagaaaagtcaagcctcagtgtc878AsnLysAspGlyIleAlaPheIleGluLysSerSerLeuSerVal245250255catccaagtaatcttatggaaaagaagccctctgcctacaacaaa923HisProSerAsnLeuMetGluLysLysProSerAlaTyrAsnLys260265270tatgggaaattcctctgcagaaagcctgtttttattatgcctcag968TyrGlyLysPheLeuCysArgLysProValPheIleMetProGln275280285agacctcaaacagaagagaaaccctttcactgtccttactgtggg1013ArgProGlnThrGluGluLysProPheHisCysProTyrCysGly290295300aataactttagaaggaagtcatacctcattgaacatcagcgaatt1058AsnAsnPheArgArgLysSerTyrLeuIleGluHisGlnArgIle305310315cacacaggtgaaaaaccttatgtttgcaatcaatgtggaaaggcc1103HisThrGlyGluLysProTyrValCysAsnGlnCysGlyLysAla320325330ttccgtcagaagacagccctcacccttcatgagaaaacacatata1148PheArgGlnLysThrAlaLeuThrLeuHisGluLysThrHisIle335340345gaggggaaaccctttatttgtatcgattgtgggaagtccttccgc1193GluGlyLysProPheIleCysIleAspCysGlyLysSerPheArg350355360cagaaggccaccctcactagacatcacaaaacacatacgggggag1238GlnLysAlaThrLeuThrArgHisHisLysThrHisThrGlyGlu365370375aaagcctatgaatgtcctcagtgtggaagtgcctttaggaagaag1283LysAlaTyrGluCysProGlnCysGlySerAlaPheArgLysLys380385390tcatacctcattgatcaccagagaactcacacaggagagaaaccg1328SerTyrLeuIleAspHisGlnArgThrHisThrGlyGluLysPro395400405tatcagtgtaatgagtgtgggaaggcatttatccagaagacaacc1373TyrGlnCysAsnGluCysGlyLysAlaPheIleGlnLysThrThr410415420ctcactgttcatcagagaactcacacaggagagaaaccctatatt1418LeuThrValHisGlnArgThrHisThrGlyGluLysProTyrIle425430435tgcaatgaatgtgggaagtccttctgccaaaagacaaccctcact1463CysAsnGluCysGlyLysSerPheCysGlnLysThrThrLeuThr440445450ctccaccagagaattcacacgggggaaaaaccctatatttgtaat1508LeuHisGlnArgIleHisThrGlyGluLysProTyrIleCysAsn455460465gaatgtgggaagtccttccgccagaaggcaatcctcactgttcat1553GluCysGlyLysSerPheArgGlnLysAlaIleLeuThrValHis470475480cacagaatacatacaggagaaaaatccaatgggtgtcctcagtgt1598HisArgIleHisThrGlyGluLysSerAsnGlyCysProGlnCys485490495gggaaagccttcagtaggaaatcaaacctcattcgccatcagaaa1643GlyLysAlaPheSerArgLysSerAsnLeuIleArgHisGlnLys500505510actcacacaggcgagaaaccatatgaatgtaaacagtgtgggaag1688ThrHisThrGlyGluLysProTyrGluCysLysGlnCysGlyLys515520525ttcttcagttgtaagtcaaacctcattgtccatcagaaaactcac1733PhePheSerCysLysSerAsnLeuIleValHisGlnLysThrHis530535540aaggtagaaaccacgggaattcagtaa1760LysValGluThrThrGlyIleGln*545gtaatgtggctttttttgtaaaaaaatgttaagtcatagtaaaccctgta1810gatgatgttgcttgcaagcgtaatatccaacagtttaaggtactatacca1860catggtaacctactgtttgccagcctgtaaaacacacacacacacacaca1910cacacacacaaatattattagacaaattagatgacaaaaatcattaagaa1960gtccaaactttttttttattactagcttcagcagacaaaaacttcctctg2010tcaaggtgttataaacatttaaaatcacattttccatttccatacatatc2060tttttgttcatcagtaataactagttggccaactgactgtggtccatgga2110ctacacagtgagtagaggttctttaaaagaaggaggtatgaactgtattt2160ctcattgcaaatacaaaataaaaattagttgttacctcctcacagttgac2210catgattctgacttctaacattacaaattagtttttactattataaacct2260ttctataaattggattatatatcatgtattctttcatatacagcttatta2310ccttcatcatgtccgtgagtctaatcattagtacgtgtggcagaagttta2360tttatttttatccagtatagaattcaattatatgattatatcacaattta2410tccattctgctgttgatggacttttacattgtttacagcttagggtcata2460ataaatcatgcttctgagaacatacttgtcttggtgtacatacatgtatt2510tctcttgtgtatatacttaggagtggaatcgctgggtcttagagcatgtg2560tgtattcagtcagatactggcagacaattcagaactttcaccacatgaga2610taattgacactgaagggaaacagctataaattttatcaatatggtgctgg2660ttcaaaccagagaattcatgctgcagggaaactcaatcaatgttattgtg2710aaaactgggaatgtgaatgtaatatatgtagaaaaacatttagccacagc2760ccaaatcttccaggcaaatgtaataaacgtgacattgccgttagccaaaa2810aaaaaaaaaaaaaa2824
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