[发明专利]组蛋白脱乙酰酶的苯并二氮杂卓和苯并哌嗪类似物抑制剂

摘要

本发明涉及用于抑制组蛋白脱乙酰酶的化合物。更具体地，本发明提供式(I)的化合物。其中A、B、D、E、X¹、X²、X³、X⁴和n如说明书中所定义。本发明还公开了一种在细胞中抑制组蛋白脱乙酰酶的方法，该方法包括将细胞与足以抑制组蛋白脱乙酰酶的量的式(I)化合物接触。

主权项

1.一种式(I)的化合物及其N-氧化物、水合物、溶剂化物、药物可接受盐、前药和络合物：其中n为0或1；X¹、X²、X³和X4独立地选自CH、C-Z和N，其中X¹、X²、X³和X⁴中的不超过两个是N，并且X¹、X²、X³和X⁴中的不超过一个是C-Z；X⁵-X⁶为C＝C；或者X¹、X²、X³和X⁴不存在，X⁵为共价键，并且X⁶独立地选自CH₂和CH(Z)，其条件是Z中的N、O或S(O)_0-1与X⁶的CH相隔至少两个碳原子；Z独立地选自卤素、-CF₃、-NO₂、-CN、-(C₀-C₆)烷基-OR¹、-(C₀-C₆)烷基-N(R¹)₂、-(C₁-C₆)烷基、-N(R¹)-C(O)-(C₁-C₆)烷基、-N(R¹)-S(O)₂-(C₁-C₆)烷基、-O-(C₂-C₆)烷基-N(R¹)(R¹)、-S-R¹、-(C₀-C₆)烷基-C(O)-OR¹、-N(R¹)-C(O)-CF₃、-N(R¹)-(C₂-C₆)烷基-N(R¹)(R¹)、-(C₀-C₇)烷基-W、-(C₂-C₇)烯基-W、-(C₂-C₇)炔基-W、-(C₀-C₅)烷基-CH＝CH-W、-C(O)-(C₁-C₇)烷基-W、-(C₀-C₃)烷基-N(R¹)-C(O)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R¹)-C(S)-(C₁-C₆)烷基-W、-C(O)-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R¹)-C(O)-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R¹)-C(O)-O-(C₁-C₆)烷基-W、-S(O)₂-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R¹)-S(O)₂-(C₁-C₆)烷基-W、-C(O)-N(R¹)₂、-(C₀-C₃)烷基-O-C(O)-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-O-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-S-(C₁-C₆)烷基-W、-N(R¹)-C(O)-OR¹、-S(O)₂-N(R¹)₂、-N(R¹)-S(O)₂R¹、-(C₀-C₇)烷基-芳基-W、-(C₀-C₇)烷基-杂芳基-W、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-芳基、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-杂芳基、-芳基、-(C₁-C₆)烷基芳基-、-杂芳基、-(C₁-C₆)烷基杂芳基-、-(C₁-C₈)杂烷基、-(C₃-C₆)环烷基、-(C₃-C₆)杂环烷基、-(C₀-C₃)烷基-N(R¹)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-S-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-O-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-O-C(O)N(R¹)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-S(O)₂N(R¹)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)S(O)₂-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-C(O)N(R¹)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)N(R¹)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-(CH＝CH)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-S-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-O-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-OC(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-S(O)₂N(R₁)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)S(O)₂-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-C(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W和-(C₀-C₃)烷基-(CH＝CH)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₅)烷基-C≡C-W、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-S-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-O-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-O-C(O)N(R¹)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-S(O)₂N(R¹)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)S(O)₂-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-C(O)N(R¹)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)N(R¹)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-(C≡C)-(C₀-C₃)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-(CH＝CH)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-(C≡C)-(C₀-C₃)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-O-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-S-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-O-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-OC(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-S(O)₂N(R₁)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)S(O)₂-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-C(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-N(R¹)C(O)N(R¹)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-(C≡C)-(C₀-C₃)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₃)烷基-(CH＝CH)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₃)烷基-(C≡C)-(C₀-C₃)烷基-杂芳基-(C≡C)_0-1-W、(C₀-C₃)烷基-C(O)-N(R¹)-(C₁-C₆)烷基-W、(C₀-C₃)烷基-C(S)-N(R¹)-(C₁-C₆)烷基-W、-(C₀-C₃)烷基-N(R₁)-C(O)-(C₁-C₆)烷基-C(O)-芳基、-(C₀-C₃)烷基-N(R₁)-C(O)-(C₁-C₆)烷基-C(O)-杂芳基、-(C₀-C₃)烷基-N(R₁)-C(O)-(C₁-C₆)烷基-C(O)-N(R₁)-芳基和-(C₀-C₃)烷基-N(R₁)-C(O)-(C₁-C₆)烷基-C(O)-N(R₁)-杂芳基，其中上述Z的每个芳基、杂芳基、环烷基和杂环基部分任选地不被取代或被一个或多个选自氧代、-OH、-CN、-(C₁-C₆)烷基、-(C₁-C₆)烷氧基、-NO₂、-N(R¹)₂、卤素、-SH、单卤代至全卤代-(C₁-C₆)烷基和-(C₂-C₄)烷基-N(R¹)₂的取代基所取代，其中两个R¹与其所连接的氮原子一起任选地形成杂环基；R¹独立地选自-H、-(C₁-C₆)烷基、-(C₁-C₆)杂烷基、-(C₃-C₆)环烷基、杂环基、-(C₀-C₆)烷基-芳基、-(C₀-C₆)烷基-杂芳基和-(C₂-C₄)烷基-N(R¹)₂，其中所述-(C₃-C₆)环烷基、杂环基、-(C₀-C₆)烷基-芳基和-(C₀-C₆)烷基-杂芳基的每个芳基、杂芳基、环烷基和杂环基部分任选地不被取代或被一个或多个选自氧代、-OH、-CN、-(C₁-C₆)烷基、-(C₁-C₆)烷氧基、-NO₂、-N(R¹)₂、卤素、芳基、杂芳基、单卤代至全卤代-(C₁-C₆)烷基和-(C₂-C₄)烷基-N(R¹)₂的取代基所取代，其中两个R¹基团与其所连接的氮原子一起任选地形成杂环基；W选自-C(O)-NH-OH、-C(O)-C₁-C₄烷基、-C(O)-N(R¹)₂、-(C₁-C₆)烷基-N(OH)-C(O)H-、-(C₁-C₆)烷基-SR¹、-(C₁-C₆)烷基-S-C(O)-(C₁-C₄)烷基、-C(O)-OR¹、-C(O)-(C₁-C₄)烷基-SH、-C(O)-(C₁-C₄)烷基-S-C(O)R¹、-C(O)-(C₁-C₄)烷基-S-杂芳基、-(C₁-C₆)烷基-NH-C(O)-(C₁-C₆)烷基-卤素、-(C₁-C₆)烷基-NH-C(O)-(C₁-C₆)烷基-SH、-(C₁-C₆)烷基-NH-C(O)-(C₁-C₆)烷基-SC(O)R¹、-C(O)-NH-(C₂-C₆)烷基-SH、-C(O)-N(R¹)-(C₀-C₆)烷基-SR¹、-C(O)-环烷基、-C(O)-杂环基、-C(O)-N(R¹)-芳基-Q、-C(O)-N(R¹)-杂芳基-Q、-C(O)-芳基、-C(O)-杂芳基和-C(O)-(C₁-C₆)烷基，其中烷基任选地不被取代或被一个或多个选自卤素、单卤代至全卤代-(C₁-C₆)烷基、C(O)-杂芳基、-C(O)-NH-杂芳基和-C(O)-NH-芳基的取代基所取代，其中前述W基团的每个芳基和杂芳基部分任选地被一个或多个选自-NH₂、-OH、-SH、-CN、-NO₂、-N(R¹)₂、卤素、单卤代至全卤代-(C₁-C₆)烷基、芳基和杂芳基的取代基所取代；E和D独立地选自-H、-(C₁-C₆)烷基、-(C₁-C₆)杂烷基、-(C₀-C₆)烷基-(C₃-C₆)环烷基、-(C₀-C₆)杂烷基-(C₃-C₆)环烷基、-(C₀-C₆)烷基-(C₃-C₆)杂环基、-(C₀-C₆)杂烷基-(C₃-C₆)杂环基、-(C₀-C₆)烷基-芳基、-(C₀-C₆)烷基-杂芳基、-(C₀-C₆)烷基-杂芳基-(C₀-C₃)烷基-芳基、-(C₀-C₆)烷基-芳基-(C₀-C₃)烷基-芳基、-(C₀-C₆)烷基-杂芳基-(C₀-C₃)烷基-杂芳基、-(C₀-C₆)烷基-芳基-(C₀-C₃)烷基-杂芳基、杂环基、-(C₁-C₆)烷基-S-R¹、-(C₁-C₆)杂烷基-S-R¹、-(C₁-C₆)烷基-O-R¹、-(C₁-C₆)杂烷基-O-R¹、-C₁-C₆烷基-W、-(C₁-C₆)杂烷基-W、-(C₁-C₆)烷基-M-(C₁-C₃)烷基-W、-(C₁-C₆)杂烷基-M-(C₁-C₃)烷基-W、-(C₁-C₆)烷基-N(R¹)₂、-(C₁-C₆)杂烷基-N(R¹)₂、-(C₁-C₆)烷基-N(R¹)-C(O)-OR¹、-(C₀-C₆)烷基-C(O)-O-(C₁-C₆)烷基、-(C₀-C₆)烷基-C(O)-O-(C₁-C₆)杂烷基、-(C₀-C₆)杂烷基-C(O)-O-(C₁-C₆)烷基、-(C₀-C₆)杂烷基-C(O)-O-(C₁-C₆)杂烷基、-(C₀-C₆)烷基-C(O)-O-(C₁-C₆)环烷基、-(C₀-C₆)杂烷基-C(O)-O-(C₁-C₆)环烷基、-(C₀-C₆)烷基-C(O)-O-(C₁-C₆)杂环基、-(C₀-C₆)杂烷基-C(O)-O-(C₁-C₆)杂环基、-(C₀-C₆)烷基-C(O)-N(R¹)₂、-(C₀-C₆)杂烷基-C(O)-N(R¹)₂和-C(O)-N(R¹)-C₂-C₆烷基-W，其中每个芳基、杂芳基、环烷基或杂环基部分任选地不被取代或被一个或多个选自R²的基团所取代；其中M选自CH₂、O、S、S(O)、S(O)₂和N(R¹)；或者C和D和与其连接的碳原子一起形成(C₃-C₆)环烷基，其中环烷基任选被取代；R²独立地选自-H、-(C₁-C₆)烷基、-(C₁-C₆)杂烷基、-(C₀-C₆)烷基-OR¹、-(C₀-C₆)杂烷基-OR¹、-(C₀-C₆)烷基-C(O)-OR¹、-(C₀-C₆)杂烷基-C(O)-OR¹、-CH＝CH-C(O)-OR¹、-C≡C-C(O)-OR¹、-CH＝CH-C(O)-N(R¹)₂、-C≡C-C(O)-N(R¹)₂、-N(R¹)-C(O)-CF₃、-C(O)-N(R¹)-CF₃、-N(R¹)-(C₁-C₆)烷基-N(R¹)₂、-N(R¹)-(C₁-C₆)杂烷基-N(R¹)₂、-(C₀-C₆)烷基-N(R¹)₂、-(C₀-C₆)杂烷基-N(R¹)₂、-N(R¹)-C(O)-(C₁-C₆)烷基、-C(O)-N(R¹)-(C₁-C₆)烷基、-N(R¹)-C(O)-(C₁-C₆)杂烷基、-C(O)-N(R¹)-(C₁-C₆)杂烷基、-N(R¹)-S(O)₂-(C₁-C₆)烷基、-N(R¹)-S(O)₂-(C₁-C₆)杂烷基、-S(O)₂-N(R¹)-(C₁-C₆)烷基、-S(O)₂-N(R¹)-(C₁-C₆)杂烷基、-O-(C₁-C₆)烷基-N(R¹)₂、-O-(C₁-C₆)杂烷基-N(R¹)₂、-S-(C₁-C₆)烷基-N(R¹)₂、-S-(C₁-C₆)杂烷基-N(R¹)₂、-S-R¹、-S(O)-(C₁-C₆)烷基、-S(O)-(C₁-C₆)杂烷基、-S(O)₂-(C₁-C₆)烷基、-S(O)₂-(C₁-C₆)杂烷基、-(C₃-C₆)环烷基、杂环基、卤素、-CF₃、-OCF₃、-C(Ph)₃、-CN、-(C₁-C₆)烷基芳基、芳基、杂芳基、-(C₁-C₆)烷基杂芳基、-(C₁-C₆)杂烷基芳基、-(C₁-C₆)杂烷基杂芳基、和-(C₁-C₆)烷基，其被选自卤素、-OH、-NO₂、-(C₀-C₆)烷基-C(O)-N(R¹)₂和-(C₀-C₆)杂烷基-C(O)-N(R¹)₂的部分所取代；A和B独立地选自-H、-(C₁-C₆)烷基、-(C₁-C₆)杂烷基、-(C₃-C₆)环烷基、杂环基、-(C₀-C₆)烷基-芳基、-(C₀-C₆)烷基-杂芳基、-(C₀-C₆)杂烷基-芳基、-(C₀-C₆)杂烷基-杂芳基、-S(O)₂-(C₀-C₆)烷基-芳基、-S(O)₂-(C₀-C₆)烷基-杂芳基、-S(O)₂-(C₀-C₆)杂烷基-芳基、-S(O)₂-(C₀-C₆)杂烷基-杂芳基、-C(O)-(C₁-C₆)烷基-芳基、-C(O)-(C₁-C₆)烷基-杂芳基、-C(O)-(C₁-C₆)杂烷基-芳基、-C(O)-(C₁-C₆)杂烷基-杂芳基、-C(O)O-(C₀-C₆)烷基-芳基、-C(O)O-(C₁-C₆)烷基-杂芳基、-C(O)O-(C₁-C₆)杂烷基-芳基、-C(O)O-(C₁-C₆)杂烷基-杂芳基、-C(O)N(R¹)-(C₁-C₆)烷基-芳基、-C(O)N(R¹)-(C₁-C₆)杂烷基-芳基、-C(O)N(R¹)-(C₁-C₆)烷基-杂芳基、-C(O)N(R¹)-(C₁-C₆)杂烷基-杂芳基、-(C₂-C₆)烷基-N(R¹)₂、-(C₂-C₆)杂烷基-N(R¹)₂、-(C₂-C₆)烷基-O(R¹)、-(C₂-C₆)杂烷基-O(R¹)、-(C₁-C₇)烷基-W、-(C₁-C₇)杂烷基-W、-(C₂-C₅)烷基-(CH＝CH)_0-1-W、-(C₂-C₅)杂烷基-(CH＝CH)_0-1-W、-(C₂-C₅)烷基-(C≡C)_0-1-W、-(C₂-C₅)杂烷基-C≡C-W、-C(O)-(C₁-C₇)烷基-W、-C(O)-(C₁-C₇)杂烷基-W、-S(O)₂-(C₁-C₆)烷基-W、-S(O)₂-(C₁-C₆)杂烷基-W、-(C₀-C₇)烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₇)杂烷基-芳基-(CH＝CH)_0-1-W、-(C₀-C₇)烷基-芳基-(C≡C)_0-1-W、-(C₀-C₇)杂烷基-芳基-(C≡C)_0-1-W、-(C₀-C₇)烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₇)杂烷基-杂芳基-(CH＝CH)_0-1-W、-(C₀-C₇)烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₇)杂烷基-杂芳基-(C≡C)_0-1-W、-(C₀-C₇)烷基-芳基-(C₀-C₄)烷基-W、-(C₀-C₇)杂烷基-芳基-(C₀-C₄)烷基-W、-(C₀-C₇)烷基-芳基-(C₀-C₄)杂烷基-W、-(C₀-C₇)杂烷基-芳基-(C₀-C₄)杂烷基-W、-(C₀-C₇)烷基-杂芳基-(C₀-C₄)烷基-W、-(C₀-C₇)杂烷基-杂芳基-(C₀-C₄)烷基-W、-(C₀-C₇)烷基-杂芳基-(C₀-C₄)杂烷基-W、-(C₀-C₇)杂烷基-杂芳基-(C₀-C₄)杂烷基-W、-S(O)₂-(C₁-C₆)烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-S(O)₂-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-S(O)₂-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)O-(C₀-C₆)烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)O-(C₀-C₆)杂烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)O-(C₀-C₆)烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)O-(C₀-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)O-(C₀-C₆)烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)O-(C₀-C₆)杂烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)O-(C₀-C₆)烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)O-(C₀-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)O-(C₀-C₆)烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)O-(C₀-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)O-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)O-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)O-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)O-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)O-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)O-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)N(R¹)-(C₀-C₆)烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)N(R₁)-(C₀-C₆)杂烷基-芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)N(R₁)-(C₀-C₆)烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)N(R₁)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)N(R₁)-(C₁-C₆)烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)N(R₁)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)N(R₁)-(C₁-C₆)烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)N(R₁)-(C₁-C₆)杂烷基-芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W、-C(O)N(R¹)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)N(R¹)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(CH＝CH)_0-1-W、-C(O)N(R¹)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)N(R¹)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(CH＝CH)_0-1-W、-C(O)N(R¹)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)N(R¹)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)烷基-(C≡C)_0-1-W、-C(O)N(R¹)-(C₁-C₆)烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W和-C(O)N(R¹)-(C₁-C₆)杂烷基-杂芳基-(C₀-C₄)杂烷基-(C≡C)_0-1-W；其中每个烷基和杂烷基部分任选被取代；并且其中每个芳基、杂芳基、环烷基或杂环基部分任选地不被取代或被一个或多个选自R²的基团所取代；并且星号*表示手性碳原子，其条件是Z、A、B、D和E中的不超过两个以部分W结束。