[发明专利]使用HSP90抑制性化合物的前列腺癌治疗

摘要

一种治疗患有前列腺癌对象的方法，包含施用有效量以下结构式代表的化合物、其互变异构体或其药学可接受盐。结构式中描述的变量如本文所定义。

主权项

1.一种治疗患有前列腺癌对象的方法，包含施用从大约2mg/m²至大约260mg/m²量的以下结构式代表的三唑酮化合物、或其互变异构体或药学可接受盐，其中：Z是OH、SH或NH₂；X是CR₄或N；R₁是H、-OH、-SH、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的环烷基、任选取代的环烯基、任选取代的杂环基、任选取代的芳基、任选取代的杂芳基、任选取代的芳烷基、任选取代的杂芳烷基、卤素、氰基、硝基、胍基、卤代烷基、杂烷基、烷氧基或环烷氧基、卤代烷氧基，-NR₁₀R₁₁、-OR₇、-C(O)R₇、-C(O)OR₇、-C(S)R₇、-C(O)SR₇、-C(S)SR₇、-C(S)OR₇、-C(S)NR₁₀R₁₁、-C(NR₈)OR₇、-C(NR₈)R₇、-C(NR₈)NR₁₀R₁₁、-C(NR₈)SR₇、-OC(O)R₇、-OC(O)OR₇、-OC(S)OR₇、-OC(NR₈)OR₇、-SC(O)R₇、-SC(O)OR₇、-SC(NR₈)OR₇、-OC(S)R₇、-SC(S)R₇、-SC(S)OR₇、-OC(O)NR₁₀R₁₁、-OC(S)NR₁₀R₁₁、-OC(NR₈)NR₁₀R₁₁、-SC(O)NR₁₀R₁₁、-SC(NR₈)NR₁₀R₁₁、-SC(S)NR₁₀R₁₁、-OC(NR₈)R₇、-SC(NR₈)R₇、-C(O)NR₁₀R₁₁、-NR₈C(O)R₇、-NR₇C(S)R₇、-NR₇C(S)OR₇、-NR₇C(NR₈)R₇、-NR₇C(O)OR₇、-NR₇C(NR₈)OR₇、-NR₇C(O)NR₁₀R₁₁、-NR₇C(S)NR₁₀R₁₁、-NR₇C(NR₈)NR₁₀R₁₁、-SR₇、-S(O)_pR₇、-OS(O)_pR₇、-OS(O)_pOR₇、-OS(O)_pNR₁₀R₁₁、-S(O)_pOR₇、-NR₈S(O)_pR₇、-NR₇S(O)_pNR₁₀R₁₁、-NR₇S(O)_pOR₇、-S(O)_pNR₁₀R₁₁、-SS(O)_pR₇、-SS(O)_pOR₇、-SS(O)_pNR₁₀R₁₁、-OP(O)(OR₇)₂或-SP(O)(OR₇)₂；R₂是-H、-OH、-SH、-NR₇H、-OR₁₅、-SR₁₅、-NHR₁₅、-O(CH₂)_mOH、-O(CH₂)_mSH、-O(CH₂)_mNR₇H、-S(CH₂)_mOH、-S(CH₂)_mSH、-S(CH₂)_mNR₇H、-OC(O)NR₁₀R₁₁、-SC(O)NR₁₀R₁₁、-NR₇C(O)NR₁₀R₁₁、-OC(O)R₇、-SC(O)R₇、-NR₇C(O)R₇、-OC(O)OR₇、-SC(O)OR₇、-NR₇C(O)OR₇、-OCH₂C(O)R₇、-SCH₂C(O)R₇、-NR₇CH₂C(O)R₇、-OCH₂C(O)OR₇、-SCH₂C(O)OR₇、-NR₇CH₂C(O)OR₇、-OCH₂C(O)NR₁₀R₁₁、-SCH₂C(O)NR₁₀R₁₁、-NR₇CH₂C(O)NR₁₀R₁₁、-OS(O)_pR₇、-SS(O)_pR₇、-NR₇S(O)_pR₇、-OS(O)_pNR₁₀R₁₁、-SS(O)_pNR₁₀R₁₁、-NR₇S(O)_pNR₁₀R₁₁、-OS(O)_pOR₇、-SS(O)_pOR₇、-NR₇S(O)_pOR₇、-OC(S)R₇、-SC(S)R₇、-NR₇C(S)R₇、-OC(S)OR₇、-SC(S)OR₇、-NR₇C(S)OR₇、-OC(S)NR₃₀R₃₁、-SC(S)NR₁₀R₁₁、-NR₇C(S)NR₁₀R₁₁、-OC(NR₈)R₇、-SC(NR₈)R₇、-NR₇C(NR₈)R₇、-OC(NR₈)OR₇、-SC(NR₈)OR₇、-NR₇C(NR₈)OR₇、-OC(NR₈)NR₁₀R₁₁、-SC(NR₈)NR₁₀R₁₁或-NR₇C(NR₈)NR₁₀R₁₁；R₃是-H、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的环烷基、任选取代的环烯基、任选取代的杂环基、任选取代的芳基、任选取代的杂芳基、任选取代的芳烷基、任选取代的杂芳烷基、羟基烷基、烷氧基烷基、卤代烷基、杂烷基、-C(O)R₇、-(CH₂)_mC(O)OR₇、-C(O)OR₇、-OC(O)R₇、-C(O)NR₁₀R₁₁、-S(O)_pR₇、-S(O)_pOR₇或-S(O)_pNR₁₀R₁₁；R₄是-H、-OH、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的环烷基、任选取代的环烯基、任选取代的杂环基、任选取代的芳基、任选取代的杂芳基、任选取代的芳烷基、任选取代的杂芳烷基、羟基烷基、烷氧基烷基、卤素、氰基、硝基、胍基、卤代烷基、杂烷基、-C(O)R₇、-C(O)OR₇、-OC(O)R₇、-C(O)NR₁₀R₁₁、-NR₈C(O)R₇、-SR₇、-S(O)_pR₇、-OS(O)_pR₇、-S(O)_pOR₇、-NR₈S(O)_pR₇、-S(O)_pNR₁₀R₁₁，或R₃和R₄与它们所连接的碳原子一起形成任选取代的环烯基、任选取代的芳基、任选取代的杂环基或任选取代的杂芳基；R₇和R₈每一次出现独立地是-H、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的环烷基、任选取代的环烯基、任选取代的杂环基、任选取代的芳基、任选取代的杂芳基、任选取代的芳烷基或任选取代的杂芳烷基；R₁₀和R₁₁每一次出现独立地是-H、任选取代的烷基、任选取代的烯基、任选取代的炔基、任选取代的环烷基、任选取代的环烯基、任选取代的杂环基、任选取代的芳基、任选取代的杂芳基、任选取代的芳烷基或任选取代的杂芳烷基；或R₃₀和R₃₁与它们所连接的氮一起形成任选取代的杂环基或任选取代的杂芳基；R₁₅每一次出现独立地是低级烷基；p每一次出现独立地是1或2；m每一次出现独立地是1、2、3或4。