[发明专利]双杂环三氮唑核苷类似物的抗肿瘤作用与应用

摘要

本发明的目的是提供一种含有双杂环三氮唑核苷类似物化合物、立体异构体、前药、药用盐、复盐和或溶剂化的化合物具有下列结构通式I,和或其立体异构体，互变异构体，前药，药学可接受的盐，复合盐和或溶剂化合物，具有抗肿瘤作用与应用。

主权项

1.本发明的目的是提供一种含有双杂环三氮唑核苷类似物化合物、立体异构体、前药、药用盐、复盐和或溶剂化的化合物具有下列结构通式I,和或其立体异构体,互变异构体,前药,药学可接受的盐,复合盐和或溶剂化合物；其特征是：所述虚线部分为不存在和或为独立的或与实线组合的任意取代的结构，选自‑C‑C‑,‑C＝C‑,‑C‑杂键,‑C＝杂键，所述X1和X2为不存在和或独立的选自但不局限于:H,‑C‑,‑S‑,‑O‑,‑NH‑；所述S1和S2为不存在和或独立的选自但不局限于:H,卤素,芳基,‑CN,‑CF3,‑OH,‑NH2,胍基,脒基,‑C(O)OH,P(O)(OH)2,‑C1,2,3,4,5,6烷基,‑C2,3,4,5,6烯基,‑C2,3,4,5,6炔基,‑C3,4,5,6,7,8,9,10环烷基,‑C3,4,5,6,7,8,9,10环烯基,芳基,‑C3,4,5,6,7,8,9,10杂环基,‑C3,4,5,6,7,8,9,10杂芳基,‑CN,‑CF3,‑OH,‑OC1,2,3,4,5,6烷基,‑NH2,‑NHC1,2,3,4,5,6烷基,‑N(C1,2,3,4,5,6烷基)2,胍基,脒基,‑SC1,2,3,4,5,6烷基,‑SOC1,2,3,4,5,6烷基,‑SO2C1,2,3,4,5,6烷基,‑NHSO2C1,2,3,4,5,6烷基,‑NHC(O)C1,2,3,4,5,6烷基,‑SO2NHC1,2,3,4,5,6烷基,‑C(O)OH,‑C(O)OC1,2,3,4,5,6烷基,‑C(O)NHC1,2,3,4,5,6烷基,P(O)(OH)2,P(O)(O1,2,3,4,5,6烷基)2,‑(CH2)1,2,3,4,5,6P(O)(OH)2,‑(CH2)1,2,3,4,5,6P(O)(OC1,2,3,4,5,6烷基)2,C3,4,5,6,7,8氨基酸基,C3,4,5,6,7,8,9,10(OH)0,1,2,3,4,5,6,7,8,9,10多羟基氧化物；所述结构的A环是不存在和或选自但不局限于:结构，形成所述结构的B环是不存在和或选自但不局限于:结构，形成所述R为不存在和或独立的选自但不局限于：H,卤素,‑CN,‑CF3,‑OH,‑NH2,胍基,脒基,‑SH,‑P(O)(OH)2,C3,4,5,6,7,8氨基酸基,‑OC1,2,3,4,5,6烷基,‑OC2,3,4,5,6烯基,‑OC2,3,4,5,6炔基,‑OC3,4,5,6,7,8,9,10环烷基,‑OC3,4,5,6,7,8,9,10环烯基,O‑芳基,‑OC3,4,5,6,7,8,9,10杂环基,‑OC3,4,5,6,7,8,9,10杂芳基,‑NHC1,2,3,4,5,6烷基,‑NHC2,3,4,5,6烯基,‑NHC2,3,4,5,6炔基,‑NHC3,4,5,6,7,8,9,10环烷基,‑NHC3,4,5,6,7,8,9,10环烯基,NH‑芳基,‑NHC3,4,5,6,7,8,9,10杂环基,‑NH3,4,5,6,7,8,9,10杂芳基,‑N(C1,2,3,4,5,6烷基)2,‑N(C2,3,4,5,6烯基)2,‑N(C2,3,4,5,6炔基)2,‑N(C3,4,5,6,7,8,9,10环烷基)2,‑N(C3,4,5,6,7,8,9,10环烯基)2,N(芳基)2,‑N(C3,4,5,6,7,8,9,10杂环基)2,‑N(C3,4,5,6,7,8,9,10杂芳基)2,‑NHSO2C1,2,3,4,5,6烷基,‑NHC(O)C1,2,3,4,5,6烷基,‑SC1,2,3,4,5,6烷基,‑SC2,3,4,5,6烯基,‑SC2,3,4,5,6炔基,‑SC3,4,5,6,7,8,9,10环烷基,‑SC3,4,5,6,7,8,9,10环烯基,S‑芳基,‑SC3,4,5,6,7,8,9,10杂环基,‑SC3,4,5,6,7,8,9,10杂芳基,‑SOC1,2,3,4,5,6烷基,‑SO2C1,2,3,4,5,6烷基,‑SO2NHC1,2,3,4,5,6烷基,‑C1,2,3,4,5,6烷基,‑C2,3,4,5,6烯基,‑C2,3,4,5,6炔基,‑C3,4,5,6,7,8,9,10环烷基,‑C3,4,5,6,7,8,9,10环烯基,‑芳基,‑C3,4,5,6,7,8,9,10杂环基,‑C3,4,5,6,7,8,9,10杂芳基,‑C(O)OH,‑C(O)OC1,2,3,4,5,6烷基,‑C(O)NHC1,2,3,4,5,6烷基,‑OP(OC1,2,3,4,5,6烷基)2,‑OP(OC2,3,4,5,6烯基)2,‑OP(OC2,3,4,5,6炔基)2,‑OP(OC3,4,5,6,7,8,9,10环烷基)2,‑OP(OC3,4,5,6,7,8,9,10环烯基)2,OP‑(O芳基)2,‑OP(OC3,4,5,6,7,8,9,10杂环基)2,‑OP(OC3,4,5,6,7,8,9,10杂芳基)2,‑NP(O)(NC1,2,3,4,5,6烷基)(OC1,2,3,4,5,6烷基),‑NP(O)(NC2,3,4,5,6烯基)(OC2,3,4,5,6烯基),‑NP(O)(NC2,3,4,5,6炔基)(OC2,3,4,5,6炔基),‑NP(O)(NC3,4,5,6,7,8,9,10环烷基)O(OC3,4,5,6,7,8,9,10环烷基),‑NP(O)(NC3,4,5,6,7,8,9,10环烯基)(OC3,4,5,6,7,8,9,10环烯基),‑NP(O)(N‑芳基)(O‑芳基),‑NP(O)(NC3,4,5,6,7,8,9,10杂环基)(OC3,4,5,6,7,8,9,10杂环基),‑NP(O)(NC3,4,5,6,7,8,9,10杂芳基)(OC3,4,5,6,7,8,9,10杂芳基),‑NP(O)(NC1,2,3,4,5,6烷基)2,‑NP(O)(NC2,3,4,5,6烯基)2,‑NP(O)(NC2,3,4,5,6炔基)2,‑NP(O)(NC3,4,5,6,7,8,9,10环烷基)2,‑NP(O)(NC3,4,5,6,7,8,9,10环烯基)2,‑NP(O)(N‑芳基)2,‑NP(O)(NC3,4,5,6,7,8,9,10杂环基)2,‑NP(O)(NC3,4,5,6,7,8,9,10杂芳基)2。