[发明专利]芳香族阳离子肽及其用途

摘要

本发明提供了芳香族阳离子肽及其用途。本发明公开了一种传感器，包括：掺杂有一含量的芳香族阳离子肽的细胞色素c；和计量仪，所述计量仪用以测量由所述芳香族阳离子肽的含量的变化引起的所述细胞色素c的特性的变化。

主权项

1.一种传感器，包括：掺杂有一含量的芳香族阳离子肽的细胞色素c；和计量仪，所述计量仪用以测量由所述芳香族阳离子肽的含量的变化引起的所述细胞色素c的特性的变化，其中，所述芳香族阳离子肽选自由以下组成的组：Tyr‑D‑Arg‑Phe‑Lys‑NH₂；2′,6′‑Dmt‑D‑Arg‑Phe‑Lys‑NH₂；Phe‑D‑Arg‑Phe‑Lys‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑Trp‑NH₂；D‑Arg‑Trp‑Lys‑Trp‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑Phe‑Met‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Lys(N^αMe)‑Phe‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Lys‑Phe(NMe)‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Lys(N^αMe)‑Phe(NMe)‑NH₂；H‑D‑Arg(N^αMe)‑2′,6′‑Dmt(NMe)‑Lys(N^αMe)‑Phe(NMe)‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑Phe‑Lys‑Trp‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑2′,6′‑Dmt‑Lys‑Trp‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑Phe‑Lys‑Met‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑2′,6′‑Dmt‑Lys‑Met‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Lys‑Phe‑Sar‑Gly‑Cys‑NH₂；H‑D‑Arg‑Ψ[CH₂‑NH]‑2′,6′‑Dmt‑Lys‑Phe‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Ψ[CH₂‑NH]Lys‑Phe‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑LysΨ[CH₂‑NH]Phe‑NH₂；H‑D‑Arg‑2′,6′‑Dmt‑Ψ[CH₂‑NH]Lys‑Ψ[CH₂‑NH]Phe‑NH₂；Lys‑D‑Arg‑Tyr‑NH₂；Tyr‑D‑Arg‑Phe‑Lys‑NH₂；2′,6′‑Dmt‑D‑Arg‑Phe‑Lys‑NH₂；Phe‑D‑Arg‑Phe‑Lys‑NH₂；Phe‑D‑Arg‑2′,6′‑Dmt‑Lys‑NH₂；D‑Arg‑2′,6′‑Dmt‑Lys‑Phe‑NH₂；H‑Phe‑D‑Arg‑Phe‑Lys‑Cys‑NH₂；Lys‑D‑Arg‑Tyr‑NH₂；D‑Tyr‑Trp‑Lys‑NH₂；Trp‑D‑Lys‑Tyr‑Arg‑NH₂；Tyr‑His‑D‑Gly‑Met；Tyr‑D‑Arg‑Phe‑Lys‑Glu‑NH₂；Met‑Tyr‑D‑Lys‑Phe‑Arg；D‑His‑Glu‑Lys‑Tyr‑D‑Phe‑Arg；Lys‑D‑Gln‑Tyr‑Arg‑D‑Phe‑Trp‑NH₂；Phe‑D‑Arg‑Lys‑Trp‑Tyr‑D‑Arg‑His；Gly‑D‑Phe‑Lys‑Tyr‑His‑D‑Arg‑Tyr‑NH₂；Val‑D‑Lys‑His‑Tyr‑D‑Phe‑Ser‑Tyr‑Arg‑NH₂；Trp‑Lys‑Phe‑D‑Asp‑Arg‑Tyr‑D‑His‑Lys；Lys‑Trp‑D‑Tyr‑Arg‑Asn‑Phe‑Tyr‑D‑His‑NH₂；Thr‑Gly‑Tyr‑Arg‑D‑His‑Phe‑Trp‑D‑His‑Lys；Asp‑D‑Trp‑Lys‑Tyr‑D‑His‑Phe‑Arg‑D‑Gly‑Lys‑NH₂；D‑His‑Lys‑Tyr‑D‑Phe‑Glu‑D‑Asp‑D‑His‑D‑Lys‑Arg‑Trp‑NH₂；Ala‑D‑Phe‑D‑Arg‑Tyr‑Lys‑D‑Trp‑His‑D‑Tyr‑Gly‑Phe；Tyr‑D‑His‑Phe‑D‑Arg‑Asp‑Lys‑D‑Arg‑His‑Trp‑D‑His‑Phe；Phe‑Phe‑D‑Tyr‑Arg‑Glu‑Asp‑D‑Lys‑Arg‑D‑Arg‑His‑Phe‑NH₂；Phe‑Tyr‑Lys‑D‑Arg‑Trp‑His‑D‑Lys‑D‑Lys‑Glu‑Arg‑D‑Tyr‑Thr；Tyr‑Asp‑D‑Lys‑Tyr‑Phe‑D‑Lys‑D‑Arg‑Phe‑Pro‑D‑Tyr‑His‑Lys；Glu‑Arg‑D‑Lys‑Tyr‑D‑Val‑Phe‑D‑His‑Trp‑Arg‑D‑Gly‑Tyr‑Arg‑D‑Met‑NH₂；Arg‑D‑Leu‑D‑Tyr‑Phe‑Lys‑Glu‑D‑Lys‑Arg‑D‑Trp‑Lys‑D‑Phe‑Tyr‑D‑Arg‑Gly；D‑Glu‑Asp‑Lys‑D‑Arg‑D‑His‑Phe‑Phe‑D‑Val‑Tyr‑Arg‑Tyr‑D‑Tyr‑Arg‑His‑Phe‑NH₂；Asp‑Arg‑D‑Phe‑Cys‑Phe‑D‑Arg‑D‑Lys‑Tyr‑Arg‑D‑Tyr‑Trp‑D‑His‑Tyr‑D‑Phe‑Lys‑Phe；His‑Tyr‑D‑Arg‑Trp‑Lys‑Phe‑D‑Asp‑Ala‑Arg‑Cys‑D‑Tyr‑His‑Phe‑D‑Lys‑Tyr‑His‑Ser‑NH₂；Gly‑Ala‑Lys‑Phe‑D‑Lys‑Glu‑Arg‑Tyr‑His‑D‑Arg‑D‑Arg‑Asp‑Tyr‑Trp‑D‑His‑Trp‑His‑D‑Lys‑Asp；和Thr‑Tyr‑Arg‑D‑Lys‑Trp‑Tyr‑Glu‑Asp‑D‑Lys‑D‑Arg‑His‑Phe‑D‑Tyr‑Gly‑Val‑Ile‑D‑His‑Arg‑Tyr‑Lys‑NH₂。