[发明专利]噬菌体与EB病毒的gp350蛋白融合载体疫苗的构建方法

权利要求书

1、一种噬菌体与EB病毒的gp350蛋白融合载体疫苗的构建方法，其特征在于它将EB病毒的gp350蛋白用间隔子GPGPG与其它外源蛋白或蛋白表位或其组合的融合蛋白相连接，并共同展示在噬菌体表面组成重组噬菌体疫苗。

2、按权利要求1所述的噬菌体与EB病毒的gp350蛋白融合载体疫苗的构建方法，其特征在于所述EB病毒的gp350蛋白编码序列如下：atggaagcggcgctgctggtgtgccagtataccattcagagcctgattcagctgacccgtgatgatccgggcttttttaacgtggaaattctggaatttccgttttatccggcgtgcaacgtgtgcaccgcggatgtgaacgcgaccattaactttgatgtgggcggcaaaaaacataaactgaacctggattttggcctgctgaccccgcataccaaagcggtgtatcagccgcgtggcgcgtttggcggcagcgaaaacgcgaccaacctgtttctgctggaactgctgggcgcgggcgaactggcgctgaccatgcgtagcaaaaaactgccgattaacattaccaccggcgaagaacagcaggtgagcctggaaagcgtggatgtgtattttcaggatgtgtttggcaccatgtggtgccatcatgcggaaatgcagaacccggtgtatctgattccggaaaccgtgccgtatattaaatgggataactgcaacagcaccaacattaccgcggtggtgcgtgcgcagggcctggatgtgaccctgccgctgagcctgccgaccagcgcgcaggatagcaactttagcgtgaaaaccgaaatgctgggcaacgaaattgatattgaatgcattatggaagatggcgaaattagccaggtgctgccgggcgataacaaatttaacattacctgcagcggctatgaaagccatgtgccgagcggcggcattctgaccagcaccagcccggtggcgaccccgattccgggcaccggctatgcgtatagcctgcgtctgaccccgcgtccggtgagccgttttctgggcaacaacagcattctgtatgtgttttatagcggcaacggcccgaaagcgagcggcggcgattattgcattcagagcaacattgtgtttagcgatgaaattccggcgagccaggatatgccgaccaacaccaccgatattacctatgtgggcgataacgcgacctatagcgtgccgatggtgaccagcgaagatgcgaacagcccgaacgtgaccgtgaccgcgttttgggcgtggccgaacaacaccgaaaccgattttaaatgcaaatggaccctgaccagcggcaccccgagcggctgcgaaaacattagcggcgcgtttgcgagcaaccgtacctttgatattaccgtgagcggcctgggcaccgcgccgaaaaccctgattattacccgtaccgcgaccaacgcgaccaccaccacccataaagtgatttttagcaaagcgccggaaagcaccaccaccagcccgaccctgaacaccaccggctttgcggcgccgaacaccaccaccggcctgccgagcagcacccatgtgccgaccaacctgaccgcgccggcgagcaccggcccgaccgtgagcaccgcggatgtgaccagcccgaccccggcgggcaccaccagcggcgcgagcccggtgaccccgagcccgagcccgcgtgataacggcaccgaaagcaaagcgccggatatgaccagcccgaccagcgcggtgaccaccccgaccccgaacgcgaccagcccgaccccggcggtgaccaccccgaccccgaacgcgaccagcccgaccctgggcaaaaccagcccgaccagcgcggtgaccaccccgaccccgaacgcgaccagcccgaccccggcggtgaccaccccgaccccgaacgcgaccattccgaccctgggcaaaaccagcccgaccagcgcggtgaccaccccgaccccgaacgcgaccagcccgaccgtgggcgaaaccagcccgcaggcgaacaccaccaaccataccctgggcggcaccagcagcaccccggtggtgaccagcccgccgaaaaacgcgaccagcgcggtgaccaccggccagcataacattaccagcagcagcaccagcagcatgagcctgcgtccgagcagcattagcgaaaccctgagcccgagcaccagcgataacagcaccagccatatgccgctgctgaccagcgcgcatccgaccggcggcgaaaacattacccaggtgaccccggcgagcaccagcacccatcatgtgagcaccagcagcccggcgccgcgtccgggcaccaccagccaggcgagcggcccgggcaacagcagcaccagcaccaaaccgggcgaagtgaacgtgaccaaaggcaccccgccgaaaaacgcgaccagcccgcaggcgccgagcggccagaaaaccgcggtgccgaccgtgaccagcaccggcggcaaagcgaacagcaccaccggcggcaaacataccaccggccatggcgcgcgtaccagcaccgaaccgaccaccgattatggcggcgatagcaccaccccgcgtacccgttataacgcgaccacctatctgccgccgagcaccagcagcaaactgcgtccgcgttggacctttaccagcccgccggtgaccaccgcgcaggcgaccgtgccggtgccgccgaccagccagccgcgttttagcaacctgagcatgctggtgctgcagtgggcgagcctggcggtgctgaccctgctgctgctgctggtgatggcggattgcgcgtttcgtcgtaacctgagcaccagccatacctataccaccccgccgtatgatgatgcggaaacctatgtg。