[发明专利]芳香族阳离子肽及其用途

权利要求书

1.一种芳香族阳离子肽，所述芳香族阳离子肽选自下述：

6-丁酸CoQ0-Phe-D-Arg-Phe-Lys-NH₂6-癸酸CoQ0-Phe-D-Arg-Phe-Lys-NH₂Arg-Arg-Dmt-PheArg-Cha-LysArg-DmtArg-Dmt-ArgArg-Dmt-LysArg-Dmt-Lys-PheArg-Dmt-Lys-Phe-CysArg-Dmt-PheArg-Dmt-Phe-LysArg-Lys-Dmt-PheArg-Lys-Phe-DmtArg-Phe-Dmt-LysArg-Phe-LysArg-Trp-LysArg-Tyr-LysArg-Tyr-Lys-PheD-Arg-D-Dmt-D-Lys-D-Phe-NH₂D-Arg-D-Dmt-D-Lys-L-Phe-NH₂D-Arg-D-Dmt-L-Lys-D-Phe-NH₂D-Arg-D-Dmt-L-Lys-L-Phe-NH₂D-Arg-Dmt-D-Lys-NH₂D-Arg-Dmt-D-Lys-Phe-NH₂D-Arg-Dmt-Lys-D-Phe-NH₂D-Arg-Dmt–Lys-NH₂D-Arg-Dmt-Lys-Phe-Cys

D-Arg-Dmt-NH₂D-Arg-L-Dmt-D-Lys-D-Phe-NH₂D-Arg-L-Dmt-D-Lys-L-Phe-NH₂D-Arg-L-Dmt-L-Lys-D-Phe-NH₂D-Arg-Phe-Lys-NH₂D-Arg-Trp-Lys-NH₂D-Arg-Tyr-Lys-NH₂Dmt-ArgDmt-LysDmt-Lys-D-Phe-NH₂Dmt-Lys-NH₂Dmt-Lys-PheDmt-Lys-PheDmt-Lys-Phe-NH₂Dmt-Phe-Arg-LysH-Arg-D-Dmt-Arg-NH₂H-Arg-D-Dmt-Lys-NH₂H-Arg-D-Dmt-Lys-Phe-NH₂H-Arg-D-Dmt-NH₂H-Arg-Dmt-Lys-Phe-NH₂H-D-Arg-2,6-二氯-L-酪氨酸-L-Lys-L-Phe-NH₂H-D-Arg-2,6-二氯酪氨酸-Lys-Phe-NH₂H-D-Arg-2,6-二氟-L-酪氨酸-L-Lys-L-Phe-NH₂H-D-Arg-2,6-二氟酪氨酸-Lys-Phe-NH₂H-D-Arg-2,6-二甲基-L-苯丙氨酸-L-Lys-L-Phe-NH₂H-D-Arg-2,6-二甲基苯丙氨酸-Lys-Phe-NH₂H-D-Arg-4-甲氧基-2,6-二甲基-L-酪氨酸-L-Lys-L-Phe-NH₂H-D-Arg-4-甲氧基-2,6-二甲基酪氨酸-Lys-Phe-NH₂H-D-Arg-Arg-Dmt-Phe-NH₂H-D-Arg-Cha-Lys-NH₂H-D-Arg-D-Dmt-D-Lys-D-Phe-NH₂

H-D-Arg-D-Dmt-Lys-Phe-NH₂H-D-Arg-D-Dmt-NH₂H-D-Arg-Dmt-D-Lys-D-Phe-NH₂H-D-Arg-Dmt-Lys-2,6-二甲基苯丙氨酸-NH₂H-D-Arg-Dmt-Lys-3-羟基苯丙氨酸-NH₂H-D-Arg-Dmt-Lys-NH₂H-D-Arg-Dmt-Lys-OHH-D-Arg-Dmt-Lys-Phe-OHH-D-Arg-Dmt-N6-乙酰基赖氨酸-Phe-NH₂H-D-Arg-Dmt-OHH-D-Arg-Dmt-Phe-Lys-NH₂H-D-Arg-Dmt-Phe-NH₂H-D-Arg-D-Phe-L-Lys-L-Phe-NH₂H-D-Arg-D-Trp-L-Lys-L-Phe-NH₂H-D-Arg-D-Tyr-L-Lys-L-Phe-NH₂H-D-Arg-L-Dmt-L-Lys-2,6-二甲基-L-苯丙氨酸-NH₂H-D-Arg-L-Dmt-L-Lys-3-羟基-L-苯丙氨酸-NH₂H-D-Arg-L-Dmt-L-Lys-D-Dmt-NH₂H-D-Arg-L-Dmt-L-Lys-D-Trp-NH₂H-D-Arg-L-Dmt-L-Lys-D-Tyr-NH₂H-D-Arg-L-Dmt-L-Lys-L-Dmt-NH₂H-D-Arg-L-Dmt-L-Lys-L-Dmt-NH₂H-D-Arg-L-Dmt-L-Lys-L-Trp-NH₂H-D-Arg-L-Dmt-L-Lys-L-Tyr-NH₂H-D-Arg-L-Dmt-L-Phe-L-Lys-NH₂H-D-Arg-L-Dmt-N6-乙酰基-L-赖氨酸-L-Phe-NH₂H-D-Arg-L-Lys-L-Dmt-L-Phe-NH₂H-D-Arg-L-Lys-L-Phe-L-Dmt-NH₂H-D-Arg-L-Phe-L-Dmt-L-Lys-NH₂H-D-Arg-L-Phe-L-Lys-L-Dmt-NH₂H-D-Arg-L-Phe-L-Lys-L-Phe-NH₂

H-D-Arg-L-Trp-L-Lys-L-Phe-NH₂H-D-Arg-L-Tyr-L-Lys-L-Phe-NH₂H-D-Arg-Lys-Dmt-Phe-NH₂H-D-Arg-Lys-Phe-Dmt-NH₂H-D-Arg-Phe-Dmt-Lys-NH₂H-D-Arg-Phe-Lys-Dmt-NH₂H-D-Arg-Tyr-Lys-Phe-NH₂H-D-Dmt-Arg-NH₂H-D-His-L-Dmt-L-Lys-L-Phe-NH₂H-D-Lys-L-Dmt-L-Lys-L-Phe-NH₂H-Dmt-D-Arg-Lys-Phe-NH₂H-Dmt-D-Arg-NH₂H-Dmt-D-Arg-Phe-Lys-NH₂H-Dmt-D-Phe-Arg-Lys-NH₂H-Dmt-Lys-D-Arg-Phe-NH₂H-Dmt-Lys-Phe-D-Arg-NH₂H-Dmt-Phe-D-Arg-Lys-NH₂H-Dmt-Phe-Lys-D-Arg-NH₂H-D-N2-乙酰基精氨酸-Dmt-Lys-Phe-NH₂H-D-N8-乙酰基精氨酸-Dmt-Lys-Phe-NH₂H-D-Phe-D-Arg-D-Phe-D-Lys-NH₂H-L-Dmt-D-Arg-L-Lys-L-Phe-NH₂H-L-Dmt-D-Arg-L-Phe-L-Lys-NH₂H-L-Dmt-L-Lys-D-Arg-L-Phe-NH₂H-L-Dmt-L-Lys-L-Phe-D-Arg-NH₂H-L-Dmt-L-Phe-D-Arg-L-Lys-NH₂H-L-Dmt-L-Phe-L-Lys-D-Arg-NH₂H-L-His-L-Dmt-L-Lys-L-Phe-NH₂H-L-Lys-D-Arg-L-Dmt-L-Phe-NH₂H-L-Lys-D-Arg-L-Phe-L-Dmt-NH₂H-L-Lys-L-Dmt-D-Arg-L-Phe-NH₂

H-L-Lys-L-Dmt-L-Lys-L-Phe-NH₂H-L-Lys-L-Dmt-L-Phe-D-Arg-NH₂H-L-Lys-L-Phe-D-Arg-L-Dmt-NH₂H-L-Lys-L-Phe-L-Dmt-D-Arg-NH₂H-L-Phe-D-Arg-L-Dmt-L-Lys-NH₂H-L-Phe-D-Arg-L-Lys-L-Dmt-NH₂H-L-Phe-L-Dmt-D-Arg-L-Lys-NH₂H-L-Phe-L-Dmt-L-Lys-D-Arg-NH₂H-L-Phe-L-Lys-D-Arg-L-Dmt-NH₂H-L-Phe-L-Lys-L-Dmt-D-Arg-NH₂H-Lys-D-Arg-Dmt-Phe-NH₂H-Lys-D-Arg-Phe-Dmt-NH₂H-Lys-Dmt-D-Arg-Phe-NH₂H-Lys-Dmt-Phe-D-Arg-NH₂H-Lys-D-Phe-Arg-Dmt-NH₂H-Lys-Phe-D-Arg-Dmt-NH₂H-Lys-Phe-Dmt-D-Arg-NH₂H-N2-乙酰基-D-精氨酸-L-Dmt-L-Lys-L-Phe-NH₂H-N7-乙酰基-D-精氨酸-Dmt-Lys-Phe-NH₂H-Phe(d5)-D-Arg-Phe(d5)-Lys-NH₂H-Phe-Arg-Phe-Lys-NH₂H-Phe-D-Arg-Dmt-Lys-NH₂H-Phe-D-Arg-Dmt-Lys-NH₂H-Phe-D-Arg-D-Phe-Lys-NH₂H-Phe-D-Arg-Lys-Dmt-NH₂H-Phe-D-Arg-Phe-D-Lys-NH₂H-Phe-D-Arg-Phe-Lys-Glu-Cys-Gly-NH₂H-Phe-D-Dmt-Arg-Lys-NH₂H-Phe-Dmt-D-Arg-Lys-NH₂H-Phe-Dmt-Lys-D-Arg-NH₂H-Phe-Lys-D-Arg-Dmt-NH₂

H-Phe-Lys-Dmt-D-Arg-NH₂L-Arg-D-Dmt-D-Lys-D-Phe-NH₂L-Arg-D-Dmt-D-Lys-D-Phe-NH₂L-Arg-D-Dmt-D-Lys-L-Phe-NH₂L-Arg-D-Dmt-D-Lys-L-Phe-NH₂L-Arg-D-Dmt-L-Lys-D-Phe-NH₂L-Arg-D-Dmt-L-Lys-D-Phe-NH₂L-Arg-D-Dmt-L-Lys-L-Phe-NH₂L-Arg-D-Dmt-L-Lys-L-Phe-NH₂L-Arg-L-Dmt-D-Lys-D-Phe-NH₂L-Arg-L-Dmt-D-Lys-D-Phe-NH₂L-Arg-L-Dmt-D-Lys-L-Phe-NH₂L-Arg-L-Dmt-D-Lys-L-Phe-NH₂L-Arg-L-Dmt-L-Lys-D-Phe-NH₂L-Arg-L-Dmt-L-Lys-D-Phe-NH₂L-Arg-L-Dmt-L-Lys-L-Phe-NH₂L-Arg-L-Dmt-L-Lys-L-Phe-NH₂Lys-Dmt-ArfLys-Dmt-D-Arg-NH₂Lys-PheLys-Phe-Arg-DmtLys-Phe-NH₂Lys-Trp-ArgLys-Trp-D-Arg-NH₂Phe-Arg-Dmt-LysPhe-Arg-Phe-LysPhe-Arg-Phe-LysPhe-Arg-Phe-LysPhe-Arg-Phe-LysPhe-Arg-Phe-LysPhe-Arg-Phe-Lys-Glu-Cys-Gly

Phe-Dmt-Arg-LysPhe-Lys-DmtPhe-Lys-Dmt-NH₂琥珀酸单酯CoQ0-Phe-D-Arg-Phe-Lys-NH₂