[发明专利]非洲爪蟾GLP-1类似物及其用途

权利要求书

1.一种含有式Ⅰ(SEQ.ID NO：1)结构的非洲爪蟾胰高血糖素样肽-1(XenGLP-1)类似物，其序列为：

His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Xaa₂-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Xaa₃-Gly-Xaa₄-Xaa₅(SEQ.ID NO:1)

其中：

Xaa₁:Ala，Gly或Aib；

Xaa₂:Lys(fatty acid analog)或Lys；

Xaa₃:Lys(fatty acid analog)或Lys；

Xaa₄:Lys(fatty acid analog)或Lys；

Xaa₅:Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-OH，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH₂，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-OH，-OH或-NH₂；

前提是所述序列不是His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-NH₂,His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-OH，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-OH，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH₂或His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-OH；

以及该类似物所成的可药用的盐、溶剂化物、螯合物或非共价复合物，基于该类似物基础上的药物前体，或上述形式类似物的任意混合物。

2.根据权利要求1所述的类似物，其中Lys(fatty acid analog)选自

这里：n选自12～20。