[发明专利]用于治疗慢性低度系统性炎症(CLGSI)和相关疾病的卵硫醇

说明书

公开了卵硫醇用于还与糖尿病相关的炎症性疾病的用途。

技术领域

本发明涉及制药行业，因为它关于卵硫醇(ovothiol)用于治疗慢性低度系统性炎症(CLGSI)的用途及相关病理学。

背景技术

卵硫醇是从各种棘皮动物的卵中分离的甲基-5-硫代组氨酸(metyl-5-thioistidine)。已表征3种形式，卵硫醇A、B和C。卵硫醇A是从海胆普通海胆(Paracentrotuslividus)的卵中分离并表征的(Palumbo,A.,d'Ischia,M.,Misuraca,G.,Prota,G.(1982)Tetrahedron Lett.,23,3207-3208；Palumbo,A.,Castellano,I.,Napolitano,A.(2017)Ovothiol:a potent natural antioxidant from marineorganisms.In Blue Biotechnology.Production and use of marine molecules.PART2:MARINE MOLECULES FOR DISEASE TREATMENT/PREVENTION AND FOR BIOLOGICALRESEARCH.由Stephane La Barre、Stephen S.Bates、Wiley编辑，第583-610页)。

卵硫醇B从扇贝Chlamyshastata中分离的(Turner,E.,Klevit,R.,Hager,L.J.,Shapiro,BM.(1987)Ovothiols,a family of redox-active mercaptohistidinecompounds from marine invertebrate eggs.Biochemistry,26,4028-4036)，以及卵硫醇C是从海胆Sphaerechinusgranularis(Palumbo,A.,Misuraca.G.,d'Ischia,M.,Donaudy,F.,Prota,G.(1984)Isolation and distribution of l-methyl-5-thiol-L-histidinedisulphide and a related metabolite in eggs from echinoderms.Comp.Biochem.Physiol.,78B,81-83)和紫色球海胆(Strongylocentrotuspurpuratus)(Turner,E.,Klevit,R.,Hopkins,P.B.,Shapiro,B.M.(1986)Ovothiol:a novel thiohistidine compoundfrom sea urchin eggs that confers NAD(P)H-02oxidoreductase activity onovoperoxidase.J.Biol.Chem.,261,13056-13063)的卵中分离的。

最近在绿色微藻细小裸藻(Euglena gracilis)中鉴定了卵硫醇A(O'Neill,E.C.,Trick,M.,Hill,L.,Rejzek,M.,Dusi,R.G.,Hamilton,C.J.,Zimba,P.V.,Henrissat,B.,Field,R.A.(2015)The transcriptome of Euglena gracilis reveals unexpectedmetabolic capabilities for carbohydrate and natural productbiochemistry.Mol.Biosyst.,11,2808-2820)。