[发明专利]一种降解藻类的生物制剂及其制备方法和应用

权利要求书

1.一种降解藻类的生物制剂，其特征在于有效成分为文昌鱼盲囊的上皮细胞中特异性表达的蛋白质。

2.一种降解藻类的生物制剂，其特征在于有效成分由以下蛋白质组成：cathepsin L,cathepsin B, cathepsin D, ferritin, trypsin-like serine protease, lysozymesC，lysozymes G, carboxypeptidase Z/N, tetraspanin, legumain, saposin B,subtilisin-like protease, arylsulfatase B, endo-beta-1,4-glucanase,methionine adenosyltransferase, pancreatic lipase-like protein, plasminogen,peroxiredoxin V, VCBP4, VCBP1, VCBP3, VCBP5, Gram-negative bacteria-bindingprotein, alpha2-macroglobulin, chitotriosidase 1-like protein, big defensin,proprotein convertase subtilisin/kexin type 1，Toll-interacting protein；蛋白质的相关序列如下：

>cathepsin L

MRLLIAVVCVAMATASPLMNPQWEVFKKAYNRVYAAEEEFARRLIFEDNLKTIQMHNEEADRGLHTFRLGVNQYADMTHKEFLENVIGGCLLDTNTSKSTADHVHEYDPTLTDLPDTVDWRDKGYVTPVKNQEQCGSCWAFSTTGSLEGQHFKSTQKLVSLSEQNLVDCSRKRGTGLPGRLMDQGFKYIKDNGGIDTEECYPYKAKNEKCNYQASCSGATLTAKRRQDEGRGALQQAVATVGPISVAIDAGHSSFQLYQSGVYHKFFCSETKMDHGVLAVGYGTEEGKDYWLVKNSWGASWGEKGYIKMSRNRHNNWGIATSASYPTV；

>cathepsin B

MLAWVVLSVLAAVSAKEFPIHQPLTQEIIDYVNTIDTTWKAGWNFQGATVSYVKGLCGVIRDPNNHKLPLKLHELNAQDIPDTFDSRTQWANCPTIKEVRDQGSCGSCWALAAVEAMSDRICVASKGSTMAHISAEDLNSCCKSCGNGCNGGFPEAAWEYWKRDGLVTGGPYGSHQGCQPYEIKPCEHHINGSRPACGKLEPTPRCKKSCESGYNVTFAKDKHYAKTAYSVSSKVQQIQMEIMTNGPVEAAFTVYADFPHYKSGVYQHESGAELGGHAVKMIGWGTEGSTPYWLIANSWNTDWGNMGFFKILRGQDECGIERDIVAGEPKLD；

>cathepsin D

MKFLSVLFALVVFASALHRIPLTKMKTVRRQLADVGITYDQVLDKDYSGKYYNIKDAPEPLTNYLDAQYYGPISIGTPAQNFQVVFDTGSSNLWVPSKKCKLSDIACLLHNKYDSTQSSTYMKNGTDFAIRYGSGSLTGFLSEDTVTIGGLKVQNQTFAEAVTQPGITFVAAKFDGILGMGYDTISVDGVVPPFYNMVQQKLVDKPVFSFYLNRDPSSTTRGELLLGGTDPKYYTGDFTFLDVTKPGYWQFKMDGIMINGKATDYCKGGCAAIADTGTSLIAGPTTEVQALNKQIGATPIPGGEYMVDCSQVSSLPPISFMLGGKAFELQGKDYVLQVTTMGQTVCVSGFLGIDVPAGPLWILGDVFIGPYYTLFDMGNNRVGFAPTAHVNTTRV；

>ferritin

MHAMMKTLTFVLLVLQCTLGARREDNQWLISREDAGDPDNQDFARQNFHEDCEAGINKQINLEMFAGYTYRSMASYFNRDDVALKGVADFFRHHSEEELEHAQLLEEFQNKRGGRVVYENLRKPEKDTWGSALEAMQAALTLEKNVNQRLINLHKTAGQHNDMQMQDFLDSHFMTEQVEGIKQIADYITNIKRVGTSGWASTCSTSTPSAAASRGNSVRRTREERNLHRTKSYL；

>trypsin-like serine protease

MIWCLLLLALAARGDAWLFSCSASDFQCSNGNCIPGSWECDGEADCSDGSDEASCSGGGTCQQGVHFFCANGLYCIDSNWVCDGDNDCGDMSDEQNCGGGSTGTTGTTAPITSFTGDCGQPAISPQNVRVVGGVQAVQGSWPWQASLKLYGGHVCGGQIIAPNWIVTAAHCVDGQSNPSQWRVSLGSHRRTSTDSTQQDFSVTRIIMHESYDSNRINNDVALMKLSGNAQFNNYVSPICLPTQDVAAGTNCVTTGWGDTGSGASTYLMQATVPIMEWNKCNSAQYMNGAITDKMICAGYDQGGKDACQGDSGGPLVCNYSGKWTLDGIVSWGYGCAQAYKPGIYTRVTQFVSWINNKMASN；

>lysozyme C

MFLAVVLVMGLVCSAHAKTYERCELARELVSRGLTSRSQAGEWICLVQHESSFRTGARGGPNWDGSYDHGLFQINDHYWCDNGGPHNDCGVSCSNLRDNNIADDVRCAKLIYQRHGFSAWYGWQNNCQGSTSSYVSGCF；

>lysozyme G

MMFLVILAIVGVATADDWQCTTSVAANGQNGQCAHVDTCPYHYFVSNKCPSYGNDVKCCYNCHLGGCSISGGSSGGTGGSGSGSYGNIMEVDTTGASSQTASQDNIWYSGVSASHQLASNDLGRLNNYKSQIFDAGNAKNMDAAVIAAIISRESRAGAALAADGTGDNGNGFGLMQVDYRYHTPAGGPYSTEHMMQGTQILIDTINCVKRNHPNWNDNMTLKGGISGYNAGCGNVQTYAGMDGGTTGEDYANDVVARAQWLKGQGF；

>carboxypeptidase Z/N

MIFAILLAALPALALAEVDSSFVFEYHRYTALRSVLLAVSQDCPDITRLYSIGQSVQGRELLVLEISDNPGQHELGEPEFKYVGNMHGNEVRGRELIILLAQYLCGEYKAGNSRIVSLVRDTRIHLMPTMNPDGFEVAANQGPDNNGWTTGRNNMQGIDLNRNFPELNSIAYSGESSGTNQDHIPIPSSYWSGTVAPETRAMITWLQSYPFVLSANMHDGDLVANYPYDTAKSGGFWGSGYAATPDDALWRDLASTYAQAHGTMATTGGGSCGFQGQGGITNGADWYSLSGGMQDFNYLHTNCYELTLELGCDKYPRESELRMEWNNNKESLLAFMEKVHIGIKGVVTDTNGNGVADAKIKVQGNAHGVNSAADGDYWRLLRPGTYSVTATKGQASQTKSCTVGSGAATTCDFTLDAAGVLSGGTTGTGRLDISM

>tetraspanin

MEAKGGMQCIKYLLFAFNLIFWITGLAMIGVGATVKIAFGDYFDFTGNAFASAPVFLIILGVFVSIIGFLGCCGAIKENYCMVTTFAGRLSLIFILEIAAGITGYVLRNDIENVIDTAMTDFMMKWTNKTEGRLAFDGVHKKFECCGVTNYTDWFDKSPNFNPNNQPNVPGSCCLNAKTEFDVKNPDDTCGEGADTTKINTEGCLLKLEGWLAQNILIIGGVGIGIAFIQVVGIIFACCLMRSIKQEYEVV；

>legumain

MLSIVMLSLFGAVLGFPADFEEAIPVAEPEPGVNWAVLIAGSTGWGNYRHQADVCHAYQILHRNGIPDERIVVMMADDLAHNIRNPTKGIIINHPDGKDVYHGVPKDYTRFDVTAKNFLRVLKGDKEGVAGIGSGKVIESGPHDNVFVYYTDHGAPGIVAMPHGGMLHADDLVTTLKEMHQENKFNKLVFYLESCESGSMFDKMLPENINIFATTAANGKESSYACYMDTKRKTYLGDLYSVNWMEDSDVEKVDKETLEQQFEKVKMLTNRSHVQEYGDVNMKNDVIGLYQSTINYPSTPLPRYKQVPHDAVPAPDVPLAILNLRLETAETEEERQTVLAELKEELNLRTTIAQTMKDIATMATDDADKAEDILVNHHRDITARACYKAAVNYFHDKCYDLSQYEHALRHMYTLVNLCEEQVPLDRVTAAMDSVC；

>saposin B

MKSVAVVLAVLLASQCLAVRPPSRRGPALVRAGGLSIGQVFKPSKVDLDLCKFCIDFSQQALNQLLNIILQVGVVGTCGDICQALADKTGSQALGVACNLLCDIEGVKEFVKIIENADLDPIYYCELLKQCTIKDDGDAKITSLDVSPKSGPQGTFMIDIEYMSKNGTGTGEMVVDIDTVDGIPLGQGFILEAQEAGSYGQKISLKAQPDPDCDPTQGPCEQWMPGVYNVNIAICNGECGSKHPHSQIYDQGMTNFTITG；

>subtilisin-like protease

MKSLRVLAVLAAVLGVAMATAPMLRLDSKTAIPNEYIVVLQKNLTNYAVGKHMNSVKTLLTGTNDTKILFEHNFRWFKAYSIRTNQKMIRHLAEQPEVRYIEANQVVKAYQAQCQDQLEATWGLVRTVERDLLLDGIYHYQGGDGEGVDAYIIDTGIYTEHSEFGGRAKWGVDTVDTPSPETDENGHGTHVAGTVMSDAWGLAKKATAIAVKVLSRSGSGSTAGVIEGVEWTGQQHSGNNKKSVANMSLGGGRSDAMNEAVKAVVEAGVVMVVAAGNEGWEACNVSPASEPTAITVGCSDNEDDFCFFSNYGTCMDIIAPGQDVTSAWIGGQFADNTISGTSMSAPHIAGIVAKYMSRQSSVPSPEEVKDFLQTTSTKDKINQIPSNSDTLNYLGFMDCGGGPDV；

>arylsulfatase B

MLRVPLLLLTGALVGLVSAQDGSQNATKPHILFIVADDLGWNDVGWHNPDVKTPVLDKLAHEGVILNQSYVNYVCTPSRTAFMTGYYPYHAGSQHLVFLPQQAQGIPYNFTFLPEKLKDLGYATHMVGKWHLGFCNWKYTPTYRGFDSFYGYYNADEDYYTHVVAGGLDLRDDKEVVNTKNGQYGTYFFTDRMVDIIEKHPADTPLFLYLPFQNVHEPLEVPERFENIYMNVQNENRRKLLGMVSALDEAVGNVTMAMKNAGLWDNTLVIFTTDNGGWIIASGNNYPLRGGKVTLWEGGTRGVAFVHGKMLQKTGYTNNEMIHAVDWFPTILAAAGGTADDAMDGVSQLDTIMSGQPSPRTEFVYNIDDVFPTKQGAIRIICTLCLRVGDYKLIEGVAGKPDGWIHPDNLTDSQLDSGDPTSGTWLFNLKDDPTEHHNLADSMPDKLKEMQAKLAEYRKSLVPAINPPPDPKSFPKNWGGAWSPGWC；

>endo-beta-1,4-glucanase

MDQDYERRLLRQQNGQNCFGSPVSSPISPMAGRESLGTSPVSSPSKDKYGDRFIPSRAGANWEIGFNSIQGMYEKTSGQARKAREANSDNGKDGLAYTCLLKNELLGAGIEDLKEQTEDRRGVLSPTTPEKRNLFRYHLTAKQASPENTDHLSPYSLSPVGKKSQKLLRSPRKQTRKISKIPFKVLDAPELQDDFYLNLVDWSATNILSVGLGTCVYLWSACTSQVTRLCDLSCDGDSVTSVNWNERGNLVAVGTHKGYVQVWDAMAGKRISMLEGHSARVGALAWNADILSSGSRDRLILQRDVRTPSVVPERRLAGHRQEVCGLKWSPDHQHLASGGNDNKRIVYKKGTFVDSFRPTNMRCTALILLALLGAARAQSYYEVTGDWGDRFQANVYIPVSQAVNGWTATLKFDKAVELEIWLAEVTSTSDGNTVFELKDMGWNANVPAGTFELSFIANTQGSAANLVGLWFNGQEVTSGGTGTGTGTGTGTGTTHRPSTVSTSHTHATAPTAAQSGTTLGVVPPVVGAYDYVDALAKSILFYEAQRAGNLPGNNRVPWRRSCCQGDGQDVGLDLSGGWFDAGDHLKLHFPLSYTITVLSWGMIEFKRAYEAAGEMANALDSIKWVTDYLIKCHPSKFEFVAQVSTHGYSQNQILVWKYPSLVQVAKLTGHSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSNKESKSVLNLYTHIR；

>methionine adenosyltransferase

MANQDTFLFTSESVGEGHPDKLCDQISDAILDAHLKKDPNAKVACEACTKTGYIMVFGEVNTTATIDYQTVVRDVIKRVGYDHSDKGFDYNTCAVIQAVEQQSPDIAQGVHEKRGAEDIGAGDQGLMFGYASDETEECMPLTCMLAHGLNRKLAELRRDGTFTWLRPDTKTQVTVEYRMSGGACVPIRVHTVVMSVQTDDVVTLDDLREQLKERVVKAVIPSRYLDDKTIYHLQPSGKFQRGGPQADAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAGYAARWVAKSLVKAGLCRRVLVQVSYAIGISHPLSVLVNSYGTCQDGMTDARLLKIVNKNFDLRPGVIVRELGLQRPIYEKTACYGHFGRMDPDFTWEQPKKLDLNV；

>pancreatic lipase-like protein

MLLSVLSILSLACAAQAAEVCYGDLGCFTNIAPFWGLNRPLSSLPDPPDVVGTKFYLYTRANPTMALRERLVADSIATLSASHFSSSKPTRMVIHGFTGSAEHAWVQTIVDELLLKEDINVITVDWADGASIGGSYGQATANSRVVGAEVAKIVNYMSAQTGANARNFHLIGHSLGCHVAGYAGDILGNVGRITALDASEPYFDGMDAIVKLDPTDALFVDVIHSDGSPFIGTLGMGTSLPTGHVDFYPNGGEYQPGCHDNFVSSVVSTGFGLLTEGYDGAEAAAACSHLRAIDYFTESINSECPFTAYPCESYDKFKDGFCMSCAGSTCSQMGYRARDHYGARGKLYLTTTDGTQPGGKFCAYHYKVQVTSSTRMEETAGRIYVTFQGPSGITDTMEVTDGDVMDLKPGVTYQKLVSSASNIGDVSRVGLRFERSSSIWDFFAAQYYTVGKVTITAGETQTSYKFCGSDTPVNNGETLQLTQVGGTC；

>plasminogen

MRTLLALLGLLALTAAQDCYVGRGSAYRGAVNVTSDGLECQPWSVQAPHGHAFTPANYPDAGLDGNYCRNPDNDLRPWCYTMDPNVRFGYCDAPQCDCLFNTGEFYKGSKATSISGLTCQRWDSQSPHQHDRTPQNYPEHDLRENYCRNPDGEPRTWCYTTDPNVRWEHCDVPKCDTADLGTCGVPAIQPTFSRIVGGSVATPGSWPWQVSLGYGSNGQHVCGATLIAPEWVLSAAHCFAQLSTNPGSFIVKVGKHNKASTDSTEQRMQVAQIIVHPRYQQDGQNTNDIALLKLTQRVQLNDYVSQACITETEAPEGAICVATGFGNTEGTGGDNYLKQVQLPSLSNAQCRSWLGSVIKSTMVCAGYEGGGSDTCQGDSGGPLTCPRLGQWFVSGVTSFGQGCADPRKPGVYTRVGYYIDWILKYTADN；

>peroxiredoxin V

MLIPVTICSLARRLPSAIGARCAIYTATAYNMPIKVGDKLPGIDLYENTPGNKVNVSELFAGKKGVLFAVPGAFTPGCSKTHLPGYVGKAGDLKAKGVQVIACVSVNDPFVMEAWGKDQKAEGKVRMLADTGAEFTKAIGLDLDATGLLGNIRSKRYSMLVEDGEVKQLNVEPDGTGLTCSLAEGLKL；

>VCBP4

MAPFTPFVLCIILAGAMAQSPFRIMTVTVPRPEVTANVGSDVKLPCFYSIPAASSGLNPTINWYKGDEGIASATKIFSLSYHGSTQIAEAYEGYELRVELESLTDPTLKLSGVRASDHGRYWCAVFDSDEHNQFGMDSKSVLLTVIDPSIQQDQGMGRPGRVELRVPAVRQVYQGEDVELTCECDDCHWTSTKSWFTVSFDDTWAATEELVATVGPCVSHQCHGGTTTVAPAFRDHFSATREALRISAAKRLDKRRYWCQVEDMTFSRGSGVDAQSVALAVESRCEGKPAGRYQHPDDCSKYYTCAEGGLQYDGISACPPGLMYDQANGYCNWATQVTCL；

>VCBP1

MKFVLGLVLLAVGAHAMTIVTVSTPEPKVEASVGGSAELKCEFDIQPNSTQPPTIAWFKGNDDFRGVERIYTGHKVWGNETERREDSFGDYIGRVEVADLDKPAIKISGIKSTDFARYWCTVAEWGVRTELGVDAKSVLLTETGHSEASIDISVSGEKDVEEGGDVEMTCRCHGCTSAAIFDWFKGAFAGSEWVTTGNYTHIAAKVDVGVLGFPNPIEIDDGFGQFSVTPSNSLRLTGAQVADAGRYWCKVTSGGSVDIKATVLKVKVPEFTCAGKADGYYPDPEDCAMYYQCLYGFPQPFHRPCGYAGMVFNPEHLYCDWAFNVGPPCGSKA；

>VCBP3

MQMFLLVSVCLGMAYGQSIMTVRTTHTEVEVHAGGTVELPCSYQLANDTQPPVISWLKGASPDRSTKVFKGNYNWQGEGLGFVESDSYKESFGDFLGRASVANLAAPTLRLTHVHPQDGGRYWCQVAQWSIRTEFGLDAKSVVLKVTGHTPSNNVHVSTAEVVQVDEGNDITMTCPCTDCANANVTWYTGPTFFENYETGTYQPLANKNQFGITWFSSEIAGRASFSGARNLVIRAAKITDAGRVWCELATGQGELDADRSSTILKVQLEPFTCDGKPTGLYADPTACDYYYQCIPGYPPLHRPCGYAGMVFNEEMQYCDWDINVPPPCGSKPV；

>VCBP5

MSVLLVSIILLLYVGPESADAVSITTVTVPDRGGWVVMWPRPGDPTWVNRIEFRCEYSISPASATPPTITWLKGVFADADRQVIYKWSSSGEVYVHPEYAGRVSVPSRTHPTLVLTDAKFDDWGRYWCRVTNEDQSDEFGTDEESLLFWYKLGYDPPTRLSQVSLDKTPVRVATGGTARLDCTGTSGREASILWVKGPTSCTQGESCDSYETVIHKSAVWGAGNPEPENITISPSFDGRVSLDADGSGSFTPTLTITDIRPSDSGRYWCAPDISEVYSNLGLLNRDAQSVVIIVNDPGTEPTCAGKPDGMYQHPADCAQFYTCSGGLSYGTNNCPAGLVFNQELQLCDWANNVICL；

>Gram-negative bacteria-binding protein

MALLAVLLFHAALWAAGEAQGTYLGCYIDTPNDRDFPHVTTMTYTNGYTTCSQYCASLGYSYIGLQYAIECFCGHTYGKHGRAAESDCYYGCSGGTGGKCGGDYRNTVWDIGDVGGGSTGTGTSDNLELVFEDTFDTLDTTKWRPEVTAGGGGNEEFQYYMGHPDNLYVQNGNLYLKPTLASEHYGDNFMTSGYIDFWHGYNYVGCFNDGGDADLTESLLTASDMNPGKCVTHCANGGYEYFGLKNTECRCGNSFGRFGHGHGCHISCPGDSGKECGGNGVTSVYGQTYGDCTSDFPQGRACYLQGSQNAPLPPIQSARVTTVESFAFKYGKVEVWAKLPTGDWIWPAIWLLPRDNVYGGWPASGEIDIMESRGNRNLYGSWGGSIGVDDMGSTLHWGPRWPYNGFQQTTASKVEVDDQEVLLVSPPTNFWDMGNFGLPSYENPWAGGGKMTPFDREFYLIFNVAVGGTNYYFPDDATNQPYPKPWSNNNSREGAMRDFWNAKNQWYPTWNGDDVAMQIQSIKVWRFV；

>alpha2-macroglobulin

MRGLLLLCGVLGSVPAQKLDPTPGPTPGTPGTFLIMAPKVVRPGRPLTLSVSILDPAAASVQVTATLLQNGRPTGTPVSGDFSRNADGTLDLVVPGALTAGSAYKLKVEGTGGLTFTEEKDLTFNSKSSSIFVQTDKGKYKPGQTVKMRALAVDAELKTKKEPFDIDIFDPQGNEIVQWRGLQNDDGLVEKEFALSDQPLLGDWKIVAMLPGGDEVEQPFGVEEYVLPKFEVTISTNSFFARTEDTLQGTFNAKYTYGKNVEGQGKVTVKLRSVGSNFRPTDNSIEHNNIAMVEGSGSFQFTRGDIEGLYGNPDQLYYGSYQLELIVEVTEGLTGNTQEATKELDLVQTKYKLESFNTPDNFKPGLQYTAYVRTSYHDGTPMLGMDLAQPVTLSKNYGWDGPTAPPAEELTIPGSGVIKIVMDAPSTANSMTLSVMYNDISETATTHTAQKAESPSSSYIQVTTSTPEVTAGEDAQFTVKSTSPIGYFSYQVLSRGNIVVVDRVEVTPEDTLKSFTVPTNTQMAPSSRMVVYWMTDTGEICNDGLTFTVKGAFENQVSLSYDKDRAEPAEDIAVTVRADPDSLVALLTVDQGVLLLQSGNDITQDKVLAELEEYDPAEDTSNSGGPEIMWRRRKRSIWWPMPTSGDDAHSVFENAGVIVLTDAMVYQKQPDYWWQWGILPVADFDLGMMEFMPAAAAGESAGGGGGRGGLQEVKRVRSFFPETWLWTNATAGADGTAVFASTVPDTITSWVASAFALNDVSGLGVADTPASMEAFRPFFVSLNLPYSVVNKEETAIQALVFNYMDVDMDVTVTLKGSSGFMHIVMDTNDVNSIGTEVAGDQAVVLTVPAGSSRSKSFPIIPKQFGAITVKVLAQSTLAADAVERQLLVEPEGEQKEYTKSFILDLGDSGNGDITKDLYLSVPQSGLVAGSAYARVSVMGDMMGSTISGLDSLLQMPYGCGEQTMITFAPNVYVMHYLNETNQVTPEIKSKALKFMTSGYQRELTYTHDDGSFSAFGSSDASGSTWLSAFVMKSFSQAMDYIYIDPKVLAKTIRWLIRQQQDTGVFSEPGNVIHKEMQGGLSSDVTMTSYVLVALMEYDKILATLDAPDSDKVDVTIAKNRAVAFLESRLDSETDVYTIVTMTYALTLAGSRRKDAAFQKMNSLATTEAGQMYWTKGESATSPPVSDDLMWTPPYHNPPSADVEMTAYALLTYLDRDDLVAGMPIMKWLTEQRNAYGGYSSTQDTVVGLQALGYFAAAVRAGGLDMTVTITSDTDTDFSHTFTVNDQNAIVLQRVEIPNVSGTLTARAQGQGMGLLQLFVRYNVDVVEAVPAFNLIATVKNSDTNSVTCETCGTYQLGGSSGMAVMEIGIPSGFYVEDADLMALVDNQAMPTLKRAERSTDNKRAVIYFDEMNASPTCVTLTSHRSMPVAKTQPSVVKVYDYYKPDVKASNIYQSETLKNTNICEVCADCTGCSGRQGRPRSAAAGLAVDTLLGVVLLLLTRLLVRQCRPTNTCEECLNVPCSELVTKLRL；

>chitotriosidase 1-like protein

MLTVLALLCVMLSLGQASVIPAQRNTYRRVCYHTNWSQYRHGVGQFFPEDIDPTLCTHAIYAFAKMTNNQLQPYEWNDDSTDWSTGMYERFNTHLKPHGVKTLLGVGGWNFGSTAFSDMAATAAGRRTFVTTSIDFLRQRNFDGLDLDWEYPAARGGRPSDKQTFTLLRKELREAFDAEGARTGRAPLLLTAAMPAGEDNAMNGYEMAEVAGYLDFLNLMAYDLHGQWETYTGLNSPLYAAGDETGDDRKLNQAFAVDMWLAGGVPPSKLNLGMGTYGRSFTTTGDNSIRAPANGGGNAGLYTREKGYLAYYEICTMLNQGATRVFHSEHLSPYAYLGNQWVGYDDVESLTYKVEYLKSKNLGGAMVWAYDIDDFSGSSCGQGRYPLMNAIKNLLETGSAGVVLPPGPTHPPINPATQAPNPGVTQGPNPVVTQAPVVVEQGNLAAVTCDSKPDGFHPDPTDCGKYFQCWGGTMWPGHCSNGLQWNQAMLGCDWPYNVNC；

>big defensin

MEKKTAYCLLFLVLLVPYTALGAVLKRAPAKKEKRAVPLAVPLVYWGASVSPAVWNWLLVTFGAAAVAAAAVTVSDNDSHSCANNRGWCRSRCFSHEYIDSWHSDVCGSYDCCRPRY；

>proprotein convertase subtilisin/kexin type 1

MGRFYAWLVLAIVAFSSHGRAEDGEDQPGHFTNTWAVEIYGGPDRADLLALDHGYENLGQIGNLEDHYLFRHKDVPHRSRRGAHQHTKRLGDDERIQWVAQQVGRARSKRGPMGQQRRQSDDTRPMTFRDPYWEKQWYLHDTRTSTNLPKLDLHVLPVWRKGITGKGIVVAVLDDGIEKDHPDLVDNYDPDASYDFNDNDDDPQPRYEETNENKHGTRCAGEIAMAANNSECGVGIAFNARIGGVRMLDGVVTDAVEASSIGFNIQHVDIYSASWGPNDDGKTVEGPEKLARAAFEKGVREGRGGKGSIFAWASGNGGSNGDNCDCDGYTSSIYTVSISSASQQGGSPWYGEKCASTLATAYSSGEYKDQKISSTDLHHECTDSHTGTSAAAPLAAGVLALALEANPNLTWRDVQHLIVWTSEYDPLSSNPGWFQNGAGLWVNSRFGYGLLNAEAMVDMALTWKTVPEKTKCEVRIENFQPRDLGNGEEIIIELETDGCRGQNHVEALEHVQVKTTIDYSRRGDLRIVLTSPSGTSTTLLDTRRQDKSQMGFQDWPFMSTHNWGEKPQGKWTLTIEDKSDHAENNGVVKDVVLILHGTPEQPAYQSGGRVYTDYNRVQGDRNVEISAAKAAPAPAADAAPARGSEERIPGSGPFGSAASVVIEEIPEKETEFLVNWQDGMNRYETDFNPVNSGPFEPSADAGSDVYMDAEDLRPWEAFKYLQRQMKSPSGQRHPAHAYNKPSSQYIRDPWVSQNALDKEANLVKYYLQLLGYES；

>Toll-interacting protein

MATKVTKRGQVMLGDLPDDFLRIEATPQQLQATADMQAAQMYAQYGFMGQSSGRLSITVAQAKLAKNYGVTRMDPYCRIRVGHAVFETPTAYNGAKNPRWNKVVHAPIPQGVNSFYLEIFDERSFTMDDRVAWGHITIPESVFNGETVDDWYTLSGRQGDDKEGMINLVLSHSTVPMMQQVPQVMPQMPMMMVPQPVYYPTVQAGVPYQVPAGQMPAQQQPPAQPAITEEDLKALQDMFPNMDAEVVRSVLEANRGNKDAAVNSLLSITAE。