[发明专利]一种与皮肤老化表征相关的易感基因检测panel及其应用

权利要求书

1.一种与皮肤老化表征相关的易感基因检测panel，其特征在于，所述检测panel用于检测人基因组DNA的皮肤老化表征相关易感基因，所述检测panel包括45个SNP位点的多重PCR扩增引物和45个SNP位点的单碱基延伸引物；

所述45个SNP位点为rs1800012、rs200519781、rs4880、rs1001179、rs10733310、rs11084111、rs2031526、rs1800795、rs185146、rs1800566、rs1805007、rs1060573、rs1426654、rs322458、rs3918242、rs1042602、rs873601、rs11084109、rs2066853、rs642742、rs1799750、rs17833789、rs12913832、rs679620、rs4268748、rs251468、rs885479、rs2228479、rs12203592、rs2071307、rs146466242、rs1015362、rs1695、rs4911414、rs10810635、rs747650、rs74653330、rs6059655、rs2303067、rs3126085、rs62543565、rs2228478、rs591058、rs1800255、rs2011616；

所述45个SNP位点的多重PCR扩增引物的序列为SEQ ID NO.1和SEQ ID NO.2、SEQ IDNO.3和SEQ ID NO.4、SEQ ID NO.5和SEQ ID NO.6、SEQ ID NO.7和SEQ ID NO.8、SEQ IDNO.9和SEQ ID NO.10、SEQ ID NO.11和SEQ ID NO.12、SEQ ID NO.13和SEQ ID NO.14、SEQID NO.15和SEQ ID NO.16、SEQ ID NO.17和SEQ ID NO.18、SEQ ID NO.19和SEQ ID NO.20、SEQ ID NO.21和SEQ ID NO.22、SEQ ID NO.23和SEQ ID NO.24、SEQ ID NO.25和SEQ IDNO.26、SEQ ID NO.27和SEQ ID NO.28、SEQ ID NO.29和SEQ ID NO.30、SEQ ID NO.31和SEQID NO.32、SEQ ID NO.33和SEQ ID NO.34、SEQ ID NO.35和SEQ ID NO.36、SEQ ID NO.37和SEQ ID NO.38、SEQ ID NO.39和SEQ ID NO.40、SEQ ID NO.41和SEQ ID NO.42、SEQ IDNO.43和SEQ ID NO.44、SEQ ID NO.45和SEQ ID NO.46、SEQ ID NO.47和SEQ ID NO.48、SEQID NO.49和SEQ ID NO.50、SEQ ID NO.51和SEQ ID NO.52、SEQ ID NO.53和SEQ ID NO.54、SEQ ID NO.55和SEQ ID NO.56、SEQ ID NO.57和SEQ ID NO.58、SEQ ID NO.59和SEQ IDNO.60、SEQ ID NO.61和SEQ ID NO.62、SEQ ID NO.63和SEQ ID NO.64、SEQ ID NO.65和SEQID NO.66、SEQ ID NO.67和SEQ ID NO.68、SEQ ID NO.69和SEQ ID NO.70、SEQ ID NO.71和SEQ ID NO.72、SEQ ID NO.73和SEQ ID NO.74、SEQ ID NO.75和SEQ ID NO.76、SEQ IDNO.77和SEQ ID NO.78、SEQ ID NO.79和SEQ ID NO.80、SEQ ID NO.81和SEQ ID NO.82、SEQID NO.83和SEQ ID NO.84、SEQ ID NO.85和SEQ ID NO.86、SEQ ID NO.87和SEQ ID NO.88、SEQ ID NO.89和SEQ ID NO.90所示的核苷酸序列；

所述45个SNP位点的单碱基延伸引物的序列为SEQ ID NO.91、SEQ ID NO.92、SEQ IDNO.93、SEQ ID NO.94、SEQ ID NO.95、SEQ ID NO.96、SEQ ID NO.97、SEQ ID NO.98、SEQ IDNO.99、SEQ ID NO.100、SEQ ID NO.101、SEQ ID NO.102、SEQ ID NO.103、SEQ ID NO.104、SEQ ID NO.105、SEQ ID NO.106、SEQ ID NO.107、SEQ ID NO.108、SEQ ID NO.109、SEQ IDNO.110、SEQ ID NO.111、SEQ ID NO.112、SEQ ID NO.113、SEQ ID NO.114、SEQ ID NO.115、SEQ ID NO.116、SEQ ID NO.117、SEQ ID NO.118、SEQ ID NO.119、SEQ ID NO.120、SEQ IDNO.121、SEQ ID NO.122、SEQ ID NO.123、SEQ ID NO.124、SEQ ID NO.125、SEQ ID NO.126、SEQ ID NO.127、SEQ ID NO.128、SEQ ID NO.129、SEQ ID NO.130、SEQ ID NO.131、SEQ IDNO.132、SEQ ID NO.133、SEQ ID NO.134和SEQ ID NO.135所示的核苷酸序列。