[发明专利]氨酰基-tRNA合成酶及其用途在审
| 申请号： | 202080015621.0 | 申请日： | 2020-02-19 |
| 公开（公告）号： | CN113454211A | 公开（公告）日： | 2021-09-28 |
| 发明（设计）人： | 关宏涛 | 申请（专利权）人： | 诺和诺德股份有限公司 |
| 主分类号： | C12N9/00 | 分类号： | C12N9/00;C07K14/605 |
| 代理公司： | 北京市金杜律师事务所 11256 | 代理人： | 邰红;刘盈盈 |
| 地址： | 丹麦*** | 国省代码： | 暂无信息 |
| 权利要求书： | 查看更多 | 说明书： | 查看更多 |
| 摘要： | |||
| 搜索关键词： | 氨酰基 trna 合成 及其 用途 | ||
1.包含SEQ ID NO:7的氨基酸序列或其变体的2-氨基异丁酸-tRNA合成酶(AibRS)，其中所述SEQ ID NO:7的变体包含215Gly。
2.根据任何前述权利要求所述的AibRS；其中所述SEQ ID NO:7的变体是式I的变体，其中式I是：
Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Phe-Xaa-Glu-Xaa-Gly-Xaa-Xaa-Xaa-Lys-Xaa-Cys-Xaa-Xaa-Cys-Gly-Xaa-Xaa-Phe-Trp-Thr-Xaa-Xaa-Xaa-Xaa-Arg-Xaa-Xaa-Cys-Gly-Asp-Xaa-Pro-Cys-Xaa-Xaa-Tyr-Xaa-Phe-Ile-Gly-Xaa-Pro-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Glu-Xaa-Arg-Xaa-Xaa-Phe-Xaa-Xaa-Phe-Phe-Glu-Xaa-Xaa-Xaa-His-Xaa-Xaa-Xaa-Xaa-Arg-Tyr-Pro-Val-Xaa-Xaa-Arg-Trp-Arg-Asp-Asp-Val-Xaa-Leu-Val-Gly-Ala-Ser-Ile-Xaa-Asp-Phe-Gln-Pro-Trp-Val-Xaa-Xaa-Gly-Xaa-Xaa-Xaa-Pro-Pro-Ala-Asn-Pro-Leu-Xaa-Ile-Ser-Gln-Pro-Xaa-Ile-Arg-Xaa-Xaa-Asp-Xaa-Asp-Xaa-Val-Gly-Xaa-Xaa-Gly-Arg-His-Xaa-Thr-Xaa-Phe-Glu-Met-Met-Ala-His-His-Ala-Phe-Asn-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Tyr-Trp-Xaa-Xaa-Glu-Thr-Val-Xaa-Xaa-Xaa-Xaa-Xaa-Phe-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Ile-Thr-Phe-Xaa-Glu-Xaa-Xaa-Trp-Xaa-Gly-Gly-Gly-Asn-Ala-Gly-Xaa-Xaa-Xaa-Glu-Val-Xaa-Xaa-Xaa-Gly-Xaa-Glu-Xaa-Ala-Thr-Leu-Val-Phe-Met-Xaa-Tyr-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Pro-Xaa-Xaa-Xaa-Xaa-Xaa-Val-Asp-Thr-Gly-Tyr-Gly-Leu-Glu-Arg-Xaa-Xaa-Trp-Xaa-Ser-Xaa-Gly-Xaa-Pro-Thr-Xaa-Tyr-Asp-Ala-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Ala-Gly-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Ile-Leu-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Ala-Gly-Xaa-Xaa-Asp-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Leu-Arg-Xaa-Xaa-Val-Ala-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Glu-Leu-Xaa-Xaa-Xaa-Xaa-Xaa-Pro-Xaa-Glu-Xaa-Xaa-Tyr-Ala-Ile-Ala-Asp-His-Thr-Xaa-Xaa-Leu-Xaa-Phe-Met-Leu-Xaa-Asp-Gly-Val-Xaa-Pro-Ser-Asn-Xaa-Xaa-Ala-Gly-Tyr-Leu-Ala-Arg-Leu-Xaa-Ile-Arg-Xaa-Xaa-Xaa-Arg-Xaa-Xaa-Xaa-Xaa-Leu-Gly-Xaa-Xaa-Xaa-Pro-Leu-Xaa-Xaa-Ile-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Pro-Glu-Xaa-Xaa-Glu-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Glu-Glu-Xaa-Xaa-Xaa-Xaa-Xaa-Thr-Xaa-Xaa-Arg-Gly-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Lys-Xaa-Xaa-Gly-Xaa-Xaa-Xaa-Xaa-Pro-Xaa-Xaa-Xaa-Leu-Xaa-Xaa-Xaa-Tyr-Xaa-Ser-His-Gly-Xaa-Xaa-Pro-Glu-Xaa-Xaa-Xaa-Glu-Xaa-Ala-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Val-Xaa-Xaa-Pro-Asp-Asn-Phe-Tyr-Xaa-Xaa-Val-Ala-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa
其中式I的每个Xaa独立地选择，并且是一个或多个氨基酸，或不存在；
其中所述式I的变体在未指定为Xaa的位置处与SEQ ID NO:7至少90％相同。
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