[发明专利]预测对标准新辅助放化疗的反应和治疗后的预后的组合物、以及预测标准疗法预后不良的患者的方法和组合物

权利要求书

1.一种组合物，用于预测癌症患者对抗癌疗法的疗效反应或抗癌疗法的预后、或确定抗癌疗法前的新辅助化疗的目标患者，该组合物包括：

一种试剂，其测量第一分子亚型和第二分子亚型的至少一种基因或由其编码的蛋白的表达水平，

其中第一分子亚型包含一种或多种选自PMP2,AGTR1,PLCXD3,TCEAL6,ANKRD1,和ARHGAP26-AS1的基因，和

第二分子亚型包括一种或多种选自PGP,SLC26A3,HIST1H4C,RUVBL2,RAB19,HIST2H2AC,和SNORD69的基因。

2.根据权利要求1所述的组合物，其特征在于，第一分子亚型还包括一或多种选自下组的基因：AADACL2,ABCA6,ABCA8,ABCA9,ABCB5,ABI3BP,ACADL,ACSM5,ACTG2,ADAMTS9-AS1,ADAMTS9-AS2,ADAMTSL3,ADCYAP1R1,ADGRB3,ADH1B,ADIPOQ,ADRA1A,AFF3,AGTR1,AICDA,ALB,ANGPTL1,ANGPTL5,ANGPTL7,ANK2,ANKS1B,ANXA8L1,APOA2,APOB,APOC3,AQP4,AQP8,ARPP21,ART4,ASB5,ASPA,ASTN1,ATCAY,ATP1A2,ATP2B2,ATP2B3,AVPR1B,B3GALT5-AS1,BCHE,BEST4,BHMT2,BLOC1S5-TXNDC5,BMP3,BRINP3,BVES,BVES-AS1,C14orf180,C1QTNF7,C7,C8orf88,CA1,CA2,CA7,CACNA2D1,CADM2,CADM3,CALN1,CARTPT,CASQ2,CAVIN2,CCBE1,CCDC144B,CCDC158,CCDC160,CCDC169,CCN5,CD300LG,CDH10,CDH19,CDKN2B-AS1,CDO1,CHRDL1,CHRM2,CHST9,CIDEA,CILP,CLCA4,CLCNKB,CLDN8,CLEC3B,CLEC4M,CLVS2,CMA1,CNGA3,CNN1,CNR1,CNTN1,CNTN2,CNTNAP4,COL19A1,CP,CPEB1,CPXM2,CR2,CRP,CTNNA3,CTSG,CYP1B1,DAO,DCLK1,DDR2,DES,DHRS7C,DIRAS2,DPP6,DPT,EBF2,ECRG4,ELAVL4,EPHA5,EPHA6,EPHA7,ERICH3,EVX2,FABP4,FAM106A,FAM133A,FAM135B,FAM180B,FDCSP,FGF10,FGF13-AS1,FGF14,FGFBP2,FGG,FGL1,FHL1,FILIP1,FLNC,FMO2,FRMD6-AS2,FRMPD4,FUT9,GABRA5,GABRG2,GALR1,GAP43,GAS1RR,GC,GCG,GDF6,GFRA1,GNAO1,GPM6A,GPR119,GPR12,GPRACR,GRIA2,GRIN2A,GTF2IP1,GUCA2B,HAND1,HAND2,HAND2-AS1,HEPACAM,HP,HPCAL4,HRG,HRK,HSPB8,HTR2B,IGSF10,IGSF11,IRX6,ISM1,KCNA1,KCNB1,KCNC2,KCNK2,KCNMA1,KCNMB1,KCNQ5,KCNT2,KCTD8,KERA,KHDRBS2,KIAA0408,KIF1A,KRT222,KRT24,KRTAP13-2,LCN10,LDB3,LEP,LGI1,LIFR,LINC00504,LINC00507,LINC00682,LINC00924,LINC01266,LINC01352,LINC01474,LINC01505,LINC01697,LINC01798,LINC01829,LINC02015,LINC02023,LINC02185,LINC02268,LINC02408,LINC02544,LIX1,LMO3,LMOD1,LOC100506289,LOC101928731,LOC102724050,LOC107986321,LOC283856,LOC440434,LOC729558,LONRF2,LRAT,LRCH2,LRRC3B,LRRC4C,LRRTM4,LVRN,LYVE1,MAB21L1,MAB21L2,MAGEE2,MAMDC2,MAPK4,MASP1,MEF2C-AS1,MEOX2,METTL24,MFAP5,MGAT4C,MGP,MICU3,MIR133A1HG,MIR8071-1,MMRN1,MORN5,MPPED2,MRGPRE,MS4A1,MS4A12,MSRB3,MUSK,MYH11,MYH2,MYLK,MYO3A,MYOC,MYOCD,MYOM1,MYOT,MYT1L,NALCN,NAP1L2,NBEA,NECAB1,NEFL,NEFM,NEGR1,NETO1,NEUROD1,NEXMIF,NEXN,NGB,NIBAN1,NLGN1,NOS1,NOVA1,NPR3,NPTX1,NPY2R,NRG3,NRK,NRSN1,NRXN1,NSG2,NTNG1,NTRK3,NUDT10,OGN,OLFM3,OMD,OTOP2,OTOP3,P2RX2,P2RY12,PAK3,PAPPA2,PCDH10,PCDH11X,PCDH9,PCOLCE2,PCP4L1,PCSK2,PDZRN4,PEG3,PENK,PGM5,PGM5-AS1,PGM5P4-AS1,PGR,PHOX2B,PI16,PIK3C2G,PIRT,PKHD1L1,PLAAT5,PLCXD3,PLD5,PLIN1,PLIN4,PLN,PLP1,PMP2,POPDC2,POU3F4,PPP1R1A,PRDM6,PRELP,PRG4,PRIMA1,PROKR1,PTCHD1,PTGIS,PTPRQ,PTPRZ1,PYGM,PYY,RANBP3L,RBFOX3,RBM20,RELN,RERGL,RGS13,RGS22,RIC3,RIMS4,RNF150,RNF180,RORB,RSPO2,SCARA5,SCGN,SCN2B,SCN7A,SCN9A,SCNN1G,SCRG1,SEMA3E,SERTM1,SERTM2,SFRP1,SFRP2,SFTPA1,SGCG,SHISAL1,SLC13A5,SLC17A8,SLC30A10,SLC4A4,SLC5A7,SLC6A2,SLC7A14,SLIT2,SLITRK2,SLITRK3,SLITRK4,SMIM28,SMYD1,SNAP25,SNAP91,SORCS1,SORCS3,SPHKAP,SPIB,SPOCK3,SST,ST8SIA3,STMN2,STMN4,STON1-GTF2A1L,STUM,SV2B,SYNM,SYNPO2,SYT10,SYT4,SYT6,TACR1,TAFA4,TCEAL2,TCEAL5,TCF23,TENM1,THBS4,TLL1,TMEFF2,TMEM100,TMEM35A,TMIGD1,TMOD1,TNNT3,TNS1,TNXB,TRARG1,TRDN,UGT2B10,UGT2B4,UNC80,VEGFD,VGLL3,VIT,VSTM2A,VXN,WSCD2,XKR4,ZBTB16,ZDHHC22,ZFHX4,ZMAT4,ZNF385B,ZNF676,和ZNF728。