[发明专利]多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用

权利要求书

1.一种多肽化合物，其选自如下化合物中的任一种：

化合物1：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Lys-Ala-Ala-Gln-Aib-Phe-Leu-Glu-Trp-Leu-Ile-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Iva-Pro-Pro-Pro-Ser-OH

化合物2：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(GGSGSG-γGlu-CO(CH₂)₁₈-COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Lys-Ala-Ala-Gln-Aib-Phe-Leu-Glu-Trp-Leu-Ile-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Iva-Pro-Pro-Pro-Ser-OH

化合物3：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(GGSGSG-γGlu-CO(CH₂)₁₈-COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Lys-Ala-Ala-Gln-Aib-Phe-Leu-Glu-Trp-Leu-Ile-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Iva-Pro-Pro-Pro-Ser-NH₂

化合物4：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Gln-Phe-Leu-Glu-Trp-Leu-Ile-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Iva-Pro-Pro-Pro-Ser-OH

化合物5：

His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Gln-Phe-Leu-Glu-Trp-Leu-Arg-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser-OH

化合物6：

His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Aib-Phe-Leu-Gln-Trp-Leu-Arg-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser-OH

化合物7：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Aib-Phe-Leu-Gln-Trp-Leu-Arg-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser-OH

化合物8：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(PEG₂-PEG₂-γGlu-CO(CH₂)₁₈COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Aib-Phe-Leu-Gln-Trp-Leu-Arg-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser- NH₂

化合物9：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(GGSGSG-γGlu-CO(CH₂)₁₈-COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Aib-Phe-Leu-Gln-Trp-Leu-Arg-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser-OH

化合物10：

His-D-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Lys(GGSGSGSG-γGlu-CO(CH₂)₁₈-COOH)-Ser-Lys-Tyr-Leu-Gln-Ser-Arg-Ala-Ala-Gln-Aib-Phe-Leu-Gln-Trp-Leu-Arg-Gln-Gly-Gly-Pro-Ser-Ser-Gly-Aib-Pro-Pro-Pro-Ser-OH。