[发明专利]治疗精神分裂症的药物制剂

说明书

必需脂肪酸（EFA）是所有细胞膜包括脑中的细胞膜的基本成份。有两系列EFA，从亚油酸衍生出的n-6和从α-亚麻酸衍生出的n-3。它们的代谢途径如表1。

表1

n-6                                                                                                                                                                n-3

18:2δ-9,12                                            ↓                                    18:3δ-9,12,15

(亚油酸)                                                        ↓                                    (α-亚麻酸)

                                                                δ-6去饱和酶

18:3δ-6,9,12                                    ↓                                18:4δ-6,9,12,15

(γ-亚麻酸)                                            ↓            硬脂艾杜糖酸(stearidoni

                                                                                        ↓                                                                    cacid)］

                                                                                    伸长

20:3δ-8,11,14                                ↓                                20:4δ-8,11,14,17,

(二高-γ-亚麻酸)                        ↓

                                                                        δ-5去饱和酶

20:4δ-5,8,11,14                        ↓                                20:5δ-5,8,11,14,17

(花生四烯酸)                                    伸长                                        (二十碳五烯酸)

22:4δ-7,10,13,16                    ↓                            22:5δ-7,10,13,16,19

(肾上腺酸)                                δ-4去饱和酶

22:5δ-4,7,10,13,16            ↓                            22:6δ-4,7,10,13,16,19

                                                                                        ↓                                            (二十二碳六烯酸)

在大多数的细胞膜中，亚油酸是一种重要的成份，但对于大脑并不是这样。从浓度来说，大脑中最重要的两种EFA是花生四烯酸（AA）和二十二碳六烯酸（DHA）。二高-γ-亚麻酸（DGLA）和二十碳五烯酸（EPA）在大脑中也是重要的，但它的浓度远低于AA和DHA。n-3和n-6系列的其它脂肪酸是微量成份，尽管如此，它们却起着重要的功能性作用。