[发明专利]来自杀菌性通透性增强蛋白的功能区的生物活性肽及其应用

权利要求书

1．一种化合物，该化合物至少具有一种BPI生物活性，并选自下列一组肽：ASQQGTAALQKELKRIKIPDYSDSFKIKH         (SEQIDNO:1)；GTAALQKELKRIKIPDYSDSFKIKHLGKGH        (SEQIDNO:2)；LQKELKRIKIPDYSDSFKIKHL                (SEQIDNO:3)；QQGTAALQKELKRIK                       (SEQIDNO:4)；或GTAALQKELKRIKIP                       (SEQIDNO:5)。

2．一种化合物，该化合物至少具有一种BPI生物活性，并选自下列一组肽：SSQISMVPNVGLKFSISNANIKISGKWKAQKRFLK   (SEQIDNO:6)；IKISGKWKAQKRFLK                       (SEQIDNO:7)；KWKAQKRFLK                            (SEQIDNO:8)；CIKISGKWKAQKRFLK                      (SEQIDNO:9)；CIKISGKWKAQKRFLKC                     (SEQIDNO:10)；NVGLKFSISNANIKISGKWKAQKRFLK           (SEQIDNO:11)；AKISGKWKAQKRFLK                       (SEQIDNO:16)；IAISGKWKAQKRFLK                       (SEQIDNO:17)；IKASGKWKAQKRFLK                       (SEQIDNO:18)；IKIAGKWKAQKRFLK                       (SEQIDNO:19)；IKISAKWKAQKRFLK                       (SEQIDNO:20)；IKISGAWKAQKRFLK                       (SEQIDNO:21)；IKISGKAKAQKRFLK                       (SEQIDNO:22)；IKISGKWAAQKRFLK                       (SEQIDNO:23)；IKISGKWKAAKRFLK                       (SEQIDNO:24)；IKISGKWKAQARFLK                       (SEQIDNO:25)；IKISGKWKAQKAFLK                       (SEQIDNO:26)；IKISGKWKAQKRALK                       (SEQIDNO:27)；IKISGKWKAQKRFAK                       (SEQIDNO:28)；IKISGKWKAQKRFLA                       (SEQIDNO:29)；IKISGAWAAQKRFLK                       (SEQIDNO:30)；IKISGKWKAAARFLK                       (SEQIDNO:31)；IAISGKWKAQKRFLA                       (SEQIDNO:32)；IKISGKWKAKQRFLK                       (SEQIDNO:47)；IKISGKFKAQKRFLK                                 (SEQIDNO:48)；IKISGKW_DKAQKRFLK                               (SEQIDNO:49)；IKISGKA_β(1-萘基)KAQKRFLK                          (SEQIDNO:50)；KRFLKKWKAQKRFLK                                 (SEQIDNO:51)；KWKAQKRFLKKWKAQKRFLK                            (SEQIDNO:54)；KRFLKKWKAQKRFLKKWKAQKRFLK                       (SEQIDNO:55)；KWKAAARFLKKWKAQKRFLK                            (SEQIDNO:57)；KWKAQKRFLKKWKAAARFLK                            (SEQIDNO:58)；KWKAAARFLKKWKAAARFLK                            (SEQIDNO:59)；KWKAAARFLKKWKAAARFLKKWKAAARFLK                  (SEQIDNO:60)；IKISGKWKAQFRFLK                                 (SEQIDNO:62)；IKISGKA_{β-(1-萘基)}KAQKRFLK                         (SEQIDNO:63)；IKISGKWKAQKRA_{β-(3-吡啶基)}LK                        (SEQIDNO:64)；QKRFLKKWKAQKRFLKKWKAQKRFLK                      (SEQIDNO:65)；A_DA_DIKISGKWKAQKRFLK                           (SEQIDNO:66)；IKISGKWKAQF_DRFLK                               (SEQIDNO:71)；IKISGKWKAQWRFLK                                 (SEQIDNO:72)；IKISGKWKAKKRFLK                                 (SEQIDNO:73)；IKISGKWKAQA_{β-(1-萘基)}RFLK                         (SEQIDNO:74)；IKISGKWKAFKRFLK                                 (SEQIDNO:75)；IKISGKA_{β-(1-萘基)}KAQFRFLK                         (SEQIDNO:78)；IKISGKWKAFFRFLK                                 (SEQIDNO:82)；IKISGKA_{β-(1-萘基)}KAFKRFLK                         (SEQIDNO:84)；IKISGKA_{β-(1-萘基)}KAFFRFLK                         (SEQIDNO:85)；KWKAQWRFLKKWKAQWRFLKKWKAQWRFLK                  (SEQIDNO:93)；CIKISGKWKAQKRPLC                                (SEQIDNO:99)；IKKRAISFLGKKWQK                                 (SEQIDNO:100)；IKISGKWKAWKRFLKK                                (SEQIDNO:102)；IKISGKWKAWKRA_{β-(1-萘基)}LKK                        (SEQIDNO:104)；IKISGKA_{β-(1-萘基)}KAQA_{β-(1-萘基)}RFLK                 (SEQIDNO:111)；KWQLRSKGKIKIFKA                                 (SEQIDNO:113)；IKISGKA_{β-(1-萘基)}KAA_{β-(1-萘基)}KRFLK                 (SEQIDNO:115)；IKISGKWKAQKRKLK                                 (SEQIDNO:116)；IKISGKWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLK               (SEQIDNO:117)；IKISGKA_{β-(1-萘基)}KAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLK                                                (SEQIDNO:118)；IKISGKWKAQERFLK                                 (SEQIDNO:132)；IKISGKWKAQKRWLK                                 (SEQIDNO:137)；IKISGKWKAEKKFLK                                               (SEQIDNO:143)；KWAFAKKQKKRLKRQWLKKF                                          (SEQIDNO:148)；KWKAQKRFLKKWKAQKAFLKKWKAQKRFLK                                (SEQIDNO:149)；KWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLKKWKAQKRFLK                                                               (SEQIDNO:150)；KWKAQKRFLKKWKAAβ_(1-萘基)A_{β-(1-萘基)}RFLK                                                              (SEQIDNO:151)；KWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLKKWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLK                                                              (SEQIDNO:152)；KWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLKKWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLKKWKAA_{β-(1-萘基)}A_{β-(1-萘基)}RFLK                                                              (SEQIDNO:153)；KA_{β-(1-萘基)}KAQA_{β-(1-萘基)}RFLKKA_{β-(1-萘基)}KAQA_{β-(1-萘基)}RFLK                                                              (SEQIDNO:156)；KWKAQWRFLKKWKAQWRFL                                           (SEQIDNO:159)；KWKAA_{β-(1-萘基)}KRFLKKWKAA_{β-(1-萘基)}KRFLK                                                              (SEQIDNO:160)；KA_{β-(1-萘基)}KAQFRFLKKA_{β-(1-萘基)}KAQFRFLK                                                              (SEQIDNO:161)；KWKAQKRF                                                      (SEQIDNO:163)；CKWKAQKRFLKMSC                                                (SEQIDNO:164)；CKWKAQKRFC                                                    (SEQIDNO:165)；IKISGKWKAQKRA_{β-(1-萘基)}LK                                       (SEQIDNO:166)；KWKAFFRFLKKWKAFFRFLK                                          (SEQIDNO:101)；IKISGKWKAAWRFLK                                               (SEQIDNO:223)；IKISGKWKAA_{β-(1-萘基)}FRFLK                                       (SEQIDNO:224)；IKISGKWKAAFRFLK                                               (SEQIDNO:225)；IKISGKWKAA_{β-(1-萘基)}ARFLK                                       (SEQIDNO:226)。