[发明专利]诊断新生物的方法-Ⅱ在审
申请号: | 200880122458.7 | 申请日: | 2008-10-23 |
公开(公告)号: | CN102099485A | 公开(公告)日: | 2011-06-15 |
发明(设计)人: | L·C·拉普安特;R·邓恩;G·P·扬;T·J·洛基特;W·J·威尔逊;P·L·莫洛伊 | 申请(专利权)人: | 临床基因组学有限公司;联邦科学技术研究组织 |
主分类号: | C12Q1/68 | 分类号: | C12Q1/68 |
代理公司: | 永新专利商标代理有限公司 72002 | 代理人: | 左路;林晓红 |
地址: | 澳大利亚*** | 国省代码: | 澳大利亚;AU |
权利要求书: | 查看更多 | 说明书: | 查看更多 |
摘要: | 本发明总体上涉及核酸分子,所述核酸分子的DNA或RNA或蛋白质表达谱的改变代表发生新生物、发生新生物的倾向性和/或新生物的进展。更具体地,本发明涉及核酸分子,所述核酸分子的DNA或RNA或蛋白质表达谱的改变代表大肠新生物(例如腺瘤或腺癌)的发生和/或进展。本发明的DNA或表达谱的用途包括但不限于结直肠新生物(例如结直肠腺癌)的诊断和/或监测。因此,本发明的另一方面涉及通过筛查一或多种核酸分子标记物的DNA或RNA或蛋白质表达谱的调变而筛查个体发生新生物、发生新生物的倾向性和/或新生物的进展的方法。 | ||
搜索关键词: | 诊断 生物 方法 | ||
【主权项】:
筛查个体发生大肠新生物或发生大肠新生物的倾向性或监测新生物的进展的方法,所述方法包括评估来自所述个体的生物学样品中的一或多种基因或转录物的表达水平,所述一或多种基因或转录物选自:(i)由以下Affymetrix探针组ID检测到的基因或转录物:200600_at 210133_at 227235_at200621_at 210139_s_at 227265_at200795_at 210298_x_at 227404_s_at200799_at 210299_s_at 227529_s_at200845_s_at 210302_s_at 227561_at200859_x_at 210495_x_at 227623_at200897_s_at 210517_s_at 227662_at200974_at 210764_s_at 227705_at200986_at 210809_s_at 227727_at201041_s_at 210946_at 227826_s_at201058_s_at 210982_s_at 227827_at201061_s_at 211161_s_at 228202_at201069_at 211548_s_at 228504_at201105_at 211596_s_at 228507_at201137_s_at 211643_x_at 228640_at201141_at 211644_x_at 228706_s_at201150_s_at 211645_x_at 228707_at201289_at 211671_s_at 228750_at201300_s_at 211696_x_at 228766_at201324_at 211719_x_at 228846_at201348_at 211798_x_at 228854_at201426_s_at 211813_x_at 228885_at201427_s_at 211848_s_at 229530_at201438_at 211889_x_at 229839_at201496_x_at 211896_s_at 230087_at201497_x_at 211959_at 230264_s_at201539_s_at 211964_at 230788_at201540_at 211985_s_at 230830_at201616_s_at 211990_at 231120_x_at201617_x_at 211991_s_at 231579_s_at201645_at 212077_at 231773_at201667_at 212091_s_at 234764_x_at201739_at 212097_at 234987_at201743_at 212136_at 236300_at201744_s_at 212158_at 236313_at201842_s_at 212185_x_at 242317_at201852_x_at 212192_at 200884_at201858_s_at 212195_at 201495_x_at201859_at 212230_at 202266_at201865_x_at 212233_at 202350_s_at201893_x_at 212265_at 202731_at201920_at 212288_at 202741_at201957_at 212386_at 202742_s_at202007_at 212387_at 202768_at202037_s_at 212397_at 202838_at202069_s_at 212414_s_at 203058_s_at202133_at 212419_at 203060_s_at202222_s_at 212464_s_at 203240_at202242_at 212667_at 203296_s_at202274_at 212671_s_at 203343_at202283_at 212713_at 203474_at202291_s_at 212730_at 203638_s_at202388_at 212764_at 203963_at202555_s_at 212859_x_at 204018_x_at202620_s_at 212956_at 204034_at202686_s_at 213068_at 204036_at202746_at 213071_at 204130_at202760_s_at 213428_s_at 204388_s_at202766_s_at 213509_x_at 204389_at202888_s_at 213624_at 204508_s_at202920_at 213746_s_at 204532_x_at202953_at 213891_s_at 204607_at202957_at 214027_x_at 204673_at202992_at 214038_at 204818_at202994_s_at 214091_s_at 204895_x_at202995_s_at 214142_at 204897_at203000_at 214414_x_at 205112_at203001_s_at 214505_s_at 205259_at203066_at 214677_x_at 205403_at203131_at 214696_at 205480_s_at203305_at 214752_x_at 205554_s_at203382_s_at 214768_x_at 205593_s_at203477_at 214777_at 205892_s_at203645_s_at 215049_x_at 205929_at203680_at 215076_s_at 206000_at203729_at 215118_s_at 206094_x_at203748_x_at 215176_x_at 206262_at203766_s_at 215193_x_at 206377_at203881_s_at 215382_x_at 206385_s_at203908_at 215388_s_at 206664_at203913_s_at 215657_at 207126_x_at203914_x_at 216207_x_at 207245_at203951_at 216401_x_at 207390_s_at203980_at 216442_x_at 207392_x_at204069_at 216474_x_at 207432_at204083_s_at 216576_x_at 207761_s_at204122_at 216834_at 208596_s_at204135_at 216984_x_at 208920_at204326_x_at 217148_x_at 209114_at204438_at 217179_x_at 209374_s_at204457_s_at 217235_x_at 209458_x_at204570_at 217258_x_at 209791_at204688_at 217378_x_at 210107_at204697_s_at 217480_x_at 210524_x_at204719_at 217546_at 210735_s_at204745_x_at 217757_at 211372_s_at204834_at 217762_s_at 211538_s_at204894_s_at 217764_s_at 211549_s_at204931_at 217767_at 211637_x_at204938_s_at 217897_at 211699_x_at204939_s_at 217967_s_at 211745_x_at204940_at 218087_s_at 212224_at204955_at 218162_at 212592_at205097_at 218224_at 212741_at205200_at 218312_s_at 212814_at205267_at 218353_at 213317_at205382_s_at 218418_s_at 213451_x_at205412_at 218468_s_at 213629_x_at205433_at 218469_at 213921_at205464_at 218559_s_at 213953_at205547_s_at 218756_s_at 214164_x_at205683_x_at 219014_at 214433_s_at205935_at 219087_at 214598_at205950_s_at 219508_at 214916_x_at206134_at 219607_s_at 215125_s_at206143_at 219669_at 215299_x_at206149_at 219799_s_at 215867_x_at206198_s_at 220026_at 216336_x_at206199_at 220037_s_at 216491_x_at206208_at 220376_at 216510_x_at206209_s_at 220834_at 217022_s_at206422_at 221541_at 217109_at206461_x_at 221667_s_at 217110_s_at206561_s_at 221747_at 217165_x_at206576_s_at 221748_s_at 217232_x_at206637_at 222043_at 217414_x_at206641_at 222162_svat 218541_s_at206710_s_at 222453_at 218546_at206784_at 222513_s_at 219059_s_at207003_at 222717_at 219543_at207080_s_at 222722_at 219796_s_at207134_x_at 223121_s_at 219948_x_at207266_x_at 223122_s_at 220075_s_at207502_at 223235_s_at 220266_s_at207961_x_at 223343_at 220468_at207977_s_at 223395_at 220645_at207980_s_at 223551_at 220812_s_at208131_s_at 223623_at 221004_s_at208370_s_at 223952_x_at 221305_s_at208383_s_at 224009_x_at 221584_s_at208399_s_at 224352_s_at 221841_s_at208450_at 224412_s_at 221896_s_at208581_x_at 224480_s_at 223484_at208747_s_at 224560_at 223597_at208763_s_at 224663_s_at 223754_at208788_at 224694_at 224342_x_at208789_at 224823_at 224989_at208791_at 224836_at 224990_at208792_s_at 224840_at 225458_at208894_at 224959_at 225728_at209047_at 224963_at 226147_s_at209074_s_at 224964_s_at 226302_at209101_at 225207_at 226594_at209116_x_at 225242_s_at 226654_at209138_x_at 225269_s_at 226811_at209147_s_at 225275_at 227052_at209156_s_at 225353_s_at 227522_at209167_at 225381_at 227682_at209170_s_at 225442_at 227725_at209191_at 225575_at 227735_s_at209209_s_at 225602_at 227736_at209210_s_at 225604_s_at 228133_s_at209283_at 225626_at 228195_at209301_at 225688_s_at 228232_s_at209312_x_at 225710_at 228241_at209335_at 225720_at 228469_at209357_at 225721_at 228961_at209373_at 225782_at 229070_at209436_at 225894_at 229254_at209457_at 225895_at 229659_s_at209496_at 226001_at 229831_at209498_at 226051_at 230595_at209612_s_at 226084_at 231925_at209613_s_at 226103_at 231975_s_at209621_s_at 226303_at 233565_s_at209651_at 226304_at 235146_at209656_s_at 226333_at 235766_x_at209667_at 226430_at 235849_at209668_x_at 226492_at 238143_at209687_at 226682_at 238750_at209735_at 226694_at 238751_at209763_at 226818_at 239272_at209868_s_at 226834_at 241994_at209948_at 226841_at 242447_at210084_x_at 227006_at 242601_at227099_s_at 227061_at 243278_at;和/或(ii)CLCA4 SGK MT1XZG16 CFL2 AOC3CA2 C1S PPAP2ACA1 SELENBP1 ZSCAN18MS4A12 MT1E IVDAQP8 ADAMTS1 SFRP1SLC4A4 ITM2A COL4A2CEACAM7 POU2AF1 GPM6BTAGLN FAM55D EPB41L3GUCA1B C6orf204 MAOAGCG AKAP12 DMDADH1B TUBB6 MSRB3UGT2B17 LGALS2 PLOD2ADAMDEC1 KIAA0828 C9orf19MT1M MGC14376 MIER3AKR1B10 PPP1R14A XDHFN1 MUC4 CLDN23MGP PKIB SGCECXCL12 PIGR FOXF2PDK4 ASPN AGR3CA4 A2M IGLJ3PYY LOC25845 QKIIGHA1 LGALS1 LOC399959TPM2 BCHE ANKRD25C6orf105 ST6GALNAC1 CRISPLD2HPGD GJA1 ANK2ADH1C SCNN1B LOC283666CLCA1 FABP4 CRYABFABP1 F13A1 ACAT1ENAM CD36 IGL@CFD SPARCL1 PBLDGUCA2B ZCWPW2 CCL8FBLN1 TNC LIFRLOC63928 MT1A HLA‑DRB1ABCA8 LOC652745 UGP2POSTN MALL IGKV1D‑13DCN GNG2 AP1S2ITLN1 DNASE1L3 EMP3COL6A2 EGR1 MMP28FCGBP CMBL UGT2A3SLC26A2 GCNT3 RGS5PGM5 SERPING1 PTGISDMN MEIS1 DUSP5GPNMB EDN3 MFAP4IGFBP5 MSN UGT1A6CLEC3B MT1G PRKAR2BLOC253012 TPSAB1 HHLA2DPT GPX3 LOC652128PCK1 CDKN2B C3CNN1 FOSB ATP2B4HSD17B2 HSPA1A HBA1PLAC8 CYBRD1 TCF21TMEM47 PTGER4 PPIDOGN MAG1 PPAP2BCALD1 BEST2 SPON1ACTG2 HLA‑DQA1 PHLDB2MGC4172 PRIMA1 RARRES2MAB21L2 MT1F ETHE1RPL24 MAFB MMP2ABCG2 FAM107A SRICCDC80 PRKACB CNTN3UGT1A1 SELM RGS2MRC1 TYROBP COL6A1HSD11B2 TNS1 FBN1ANPEP MYH11 MXD1MATN2 ITM2C PLCE1PRNP CES2 KCNMB1ABI3BP MS4A4A CALM1HLA‑C PDGFRA HLA‑DPB1NDE1 CA12 SMOC2SRPX FKBP5 LOC285382WWTR1 HSPB8 CLIC5HMGCS2 TPSB2 APOELOC646627 FGL2 SERPINF1KRT20 C1QB PPP1R12BKLF4 ANGPTL1 HSPB6FHL1 MEP1A FNBP1ARL14 GUCY1A3 C4orf34LUM UGDH SORBS2SORBS1 DUSP1 GPA33METTL7A C2orf40 GALNAC4S‑6STFAM129A PLN CFHR1SCARA5 UGT2B15 MGC13057SI PDLIM3 C10orf56ACTA2 TP53INP2 SULT1A1CD177 ATP8B1 TTRAPC10orf99 ANK3 CCL28COL15A1 CTGF IDH3ANR3C2 MUCDHL EDG2DHRS9 SDPR UGT1A8LMOD1 COL14A1 RAB27AEFEMP1 DSCR1 ANTXR1GREM1 CITED2 EMP1IL1R2 MT1H CSRP1LOC387763 NEXN PLEKHC1TIMP3 MUC2 LOC572558MYLK NID1 FOXP2CLDN8 HBB HSPA2RDX GCNT2 ATP1A2TSPAN7 C20orf118 TNXBTNFRSF17 SLC20A1 FUCA1SYNPO2 CD14 MRGPRFVIM KCTD12 HIGD1ASMPDL3A RBMS1 MFSD4P2RY14 PTRF AXLCHGA TSPAN1 AQP1C15orf48 UGT1A9 MAP1BCOL3A1 COX7A1 PALLDCYR61 MUC12 MPEG1TRPM6 PDCD4 KLHL5OSTbeta CAV1 TCEAL7IGLV1‑44 FAM46C FILIP1LVSIG2 LRIG1 IQGAP2IGHM HLA‑DPA1 PRDX6LRRC19 C1orf115 RAB31CD163 HBA2 LOC96610CEACAM1 EDIL3 FGFR2TIMP2 DES PAPSS2ENTPD5 MT2A XLKD1DDR2 KCNMA1 SMTNCHRDL1 GAS1 C8orf4SRGN TBC1D9 SDCBP2PDE9A C7 CCL11PMP22 P2RY1 ELOVL5FLNA NR3C1 FOXF1STMN2 STOM RELL1MYL9 CKB PNMA1SEMA6D CLU LOC339562PADI2 SLC26A3 PALM2‑AKAP2SEPP1 SDC2 PAG1TGFB1I1 SST HCLS1SFRP2 HLA‑DRA RGS1UGT1A3 TSC22D3 FXYD6MS4A7 IL6ST OLFML3ALDH1A1 C1QC COL6A3其中相对于对照水平而言组(i)和/或组(ii)的基因或转录物的较低表达水平代表新生性大肠细胞或倾向于发生新生状态的细胞。
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