[发明专利]噻唑烷衍生物和其治疗用途

摘要

本发明提供了氘化噻唑烷衍生物和包含这些化合物的组合物，它们是可用于治疗高血糖疾病或病症、特别是糖尿病的药剂。本披露还提供了一种使用这些氘化噻唑烷衍生物治疗高血糖疾病或病症、特别是糖尿病的方法。

主权项

1.一种式(I)化合物，(I)，或其立体异构体、互变异构体、前药或药学上可接受的盐或溶剂化物，其中R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²、R¹³、R¹⁴、R¹⁵、R¹⁶、R¹⁷、R¹⁸、R¹⁹、R²⁰、R²¹、R²²、R²³、R²⁴、R²⁵、R²⁶、R²⁷、R²⁸、R²⁹和R³⁰各自独立地选自氢和氘；并且R¹、R²、R³、R⁴、R⁵、R⁶、R⁷、R⁸、R⁹、R¹⁰、R¹¹、R¹²、R¹⁴、R¹⁵、R¹⁶、R¹⁷、R¹⁸、R¹⁹、R²⁰、R²¹、R²²、R²³、R²⁴、R²⁵、R²⁶、R²⁷、R²⁸、R²⁹或R³⁰中的至少一个是氘。