[发明专利]一个与抗癌基因P53相作用的人类新基因P53BP3无效
| 申请号： | 97106700.7 | 申请日： | 1997-11-07 |
| 公开（公告）号： | CN1054399C | 公开（公告）日： | 2000-07-12 |
| 发明（设计）人： | 敖世洲;周锐 | 申请（专利权）人： | 中国科学院上海生物化学研究所 |
| 主分类号： | C12N15/12 | 分类号： | C12N15/12 |
| 代理公司： | 上海华东专利事务所 | 代理人： | 费开逵 |
| 地址： | 20003*** | 国省代码： | 上海;31 |
| 权利要求书： | 查看更多 | 说明书： | 查看更多 |
| 摘要： | 本发明涉及一种与抗癌基因编码产物Ｐ５３相作用的人体蛋白质基因Ｐ５３ＢＰ３，它的ｃＤＮＡ由５０５５核苷酸组成，编码序列编码８１５个氨基酸的蛋白质。它在人体的正常组织和肿瘤细胞株中广泛表达。Ｐ５３ＢＰ３基因定位在第１２号染色体Ｐ１１．２—１２．１区段。 | ||
| 搜索关键词： | 一个 抗癌 基因 p53 作用 人类 p53bp3 | ||
【主权项】：
1、一种与抗癌基因编码产物P53相作用的人体蛋白质基因P53BP3，其特征在于它是通过酵母双向杂交系统获得，以下是所述人P53BP3基因的DNA核苷酸及相应的氨基酸序列：-2046GAATTCTACTCGGTGGTTTCCCTCTGTAGGGTAGTTGGGAGCTTTGGAAGGATGTATGGG-1986CCTGGAGGTACAAGCTCCAAGCCCTTTAGCCAACCAGTTGTTGACGCCCTGGGGCGCAGC-1926ATCATAGGCTGTATGAGGAGAGTAGATACCGACTCTGTTCTCCAGAGCCCGGATCACCAG-1866GCGCTCCTTCCATGTGTTCCAGGTTATGCGCTTCATGGGTCGGAAGATAGGCGGATGGTA-1806GGAGAGAATGAGGTCTGCCTTCTTTTGCAGCACCTCCTCCATCACTTCCTCAGTCAGGTC-1746ATTGGTCAGGAAGAGTGTATTTACAGTATGTGGTGGGCTTGGTTCCACCAGTAATCCAAC-1686ATTGTCCCAACTCTCAGCAAACGAGAGGGATGCAAAGTCATTCAAGGAAGAAAGGAGAGC-1626CTTCAAATCCATGAAGGAACGGGAAGAATTGCAGATCAGGGAATCTACAAACCGGACTGT-1566CGTGGGGACTGGGCGTACGCAaGATGACAACATACAGAAATCAGGTAAAGTTCAAGTTTC-1506TGATGTCAAAACAAAGAAAATGGTACACAGGTATACTTTAGGCCTGGATCTTTGAGGCAT-1446CAAAACATATGGGCAAAAGAGCTGTCGTCATAGAGATCTGGGTTCAAATAGTGGCTCTGC-1386CACTTACCAGCACACTGTAACTTAGGTAAGCCATTTAACCTCTCCAATCTTGTTTTCTCA-1326CCTACGAAACAGAGATACTATAACCCACTTCACAGGCCATCCAGAGGAGCTAATGAATTA-1266TGTAACCTAGCAAAGCCTGGTACATAATACACAAACGTCCATCCCATCTCCTGCCTTGCA-1206CACCCTTGTTCTTATTCTCCCTACCCTTGCTTCAACCAACCTCCTCCCTAATCCATTTCT-1146CTAAATATTACCTTTCCTTTTCCCAAGCCCCTCCAACTTCTTAAATAAAACTTTTCTTGA-1086CCTCCCTTTTCAGCATCCTTCCCAAGGCTCCCCACCCCTCAGTATTCTCATAATTCTGTG-1026TGTGCCCATTATGCTAAAGCTACTATGTAATAGGAACTAACTTCAATAAATCTCAGTATC-966ACTAATATAAGCCAGCACTAAATGCTTACTGCATAGAATGACACTGCCCGCCTCCCCTGA-906TTGCAACAGAATTTGGAGTTGGGGTGGTATATACTGGCATTACAATGTGCTTTACCAAAA-846AACAGAATAATGTGGCGGGGCGCCTGTAATCCCGCGGCCGCGTCGACATAGGGCCTTTCC-786GCCTGCGGGCCCAGTGAGTCGACACGGTGGGGGCCCGCGATCCCCGGGACTTACCACTGA-726ATAAATCCAGTCCAGCGTGCGACGACTTACTGGCTTCATGGGGTCGCAGCCGCCGCTGGG-666GTCTCCGCTGTCTCGCGAGGAGGGTGAAGCGCCCCGCCTGCTCCCGCTTCGGAGGGTAGG-606CGGAGAAGTCGCCGGGTACGCCTTCGCGGATCCTGCCGACACCGACCTAGCTTTCTGGGC-546TGCCGGGAGCTCGCGGCGAGCGCCCCAGCCAGGCCTGCGCCGGCATCCTCCGAGATAATG-486GCATCAGCTGCTAAGGAATTTAAAATGGACAACTTTTCACCTAAAGCTGGCACTAGCAAA-426TTGCAACAGACAGTACCAGCTGATGCATCTCCTGATTCTAAGTGTCCTATATGCTTGGAT-366AGATTTGATAATGTGTCTTACTTAGATCGCTGCTTACATAAGTTCTGAAAACGCTGTGTA-306CAGGAGTGGTCAAAAAACAAAGCTGAATGCCCACTATGTAAACAGCCCTTTGATTCTATT-246TTCCATTCTGTGAGGGCAGAAGATGACTTCAAGGAGTATGTCCTAAGGCCTTCGTATAAT(后续)-186GGTTCTTTTGTCACCCCTGATCGACGATTTCGCTACCGTACAACTCTGACAAGGGAACGA-126AATGCTTCTGTGTATTCACCTAGTGGTCCTGTGAACAGAAGAACAACAACTCCACCGGAT-66AGTGGAGTACTGTTTGAAGGGTTAGGCATTTCAACAAGACCTAGAGATGTTGAAATTCCT-6CAGTTTATGAGACAGATTGCAGTAAGGAGGCCAACTACGGCAGATGAAAGATCTTTGCGGMRQIAVRRPTTADERSLR55AAAATTCAAGAACAAGATATTATTAATTTTAGACGAACTCTTTATCGTGCTGGTGCTCGAKIQEQDIINFRRTLYRAGAR115GTTAGAAATATTGAAGATGGTGGCCGCTACAGGGATATTTCAGCTGAATTTTTCCGTAGAVRNIEDGGRYRDISAEFFRR175AATCCAGCTTGCCTTCACAGATTAGTCCCCTGGTTAAAACGTGAACTTACAGTTCTTTTTNPACLHRLVPWLKRELTVLF235GGAGCTCATGGATCTTTAGTGAATATTGTCCAGCATATTATCATGAGTAATGTTACTCGCGAHGSLVNIVQHIIMSNVTR295TATGACTTGGAGAGTCAGGCATTTGTGTCTGATTTAAGACCATTTTTACTTAATCGAACTYDLESQAFVSDLRPFLLNRT355GAGCATTTTATACATGAATTTATCAGTTTTGCCCGATCTCCTTTTAACATGGCAGCCTTTEHFIHEFISFARSPFNMAAF415GACCAGCATGCCAATTATGATTGCCCTGCTCCTTCATACGAAGAAGGCAGCCATTCTGATDQHANYDCPAPSYEEGSHSD475TCTTCAGTCATAACAATATCTCCAGATGAGGCTGAGACCCAAGAGCTGGATATTAATGTASSVITISPDEAETQELDINV535GCCACTGTTAGTCAGGCACCATGGGATGATGAAACTCCAGGACCATCTTACTCAAGCTCAATVSQAPWDDETPGPSYSSS595GAGCAGGTACACGTTACTATGTCTTCTCTTTTAAATACTTCTGACAGTTCAGATGAAGAAEQVHVTMSSLLNTSDSSDEE655CTTGTCACAGGAGGAGCCACGTCTCAGATACAAGGAGTACAAACCAATGACGACCTAAATLVTGGATSQIQGVQTNDDLN715AATGACAGTGATGATTCTTCAGATAATTGTGTCATTGTTGGGTTTGTTAAACCACTAGCTNDSDDSSDNCVIVGFVKPLA775GAGAGGACCCCAGAACTTGTTGAACTGTCCTCTGATTCTGAGGACTTAGGTTCTTATGAGERTPELVELSSDSEDLGSYE835AAAATGGAGACAGTGAAGACACAAGAACAGGAGCAATCTTACAGTTCTGGTGATAGCGATKMETVKTQEQEQSYSSGDSD895GTTAGTAGATGCTCATCTCCACACTCTGTCCTTGGAAAGGATGAACAAATAAATAAAGGTVSRCSSPHSVLGKDEQINKG955CATTGTGATTCTAGTACAAGAATCAAATCAAAGAAGGAAGAGAAACGATCTACATCATTGHCDSSTRIKSKKEEKRSTSL1015TCATCTCCCAGAAACCTGAACTCATCTGTAAGAGGAGACAGAGTATATTCTCCATATAACSSPRNLNSSVRGDRVYSPYN1075CATAGACACAGAAAGAGGGGAAGATCAAGAAGTTCAGATTCACGTTCTCAGAGTAGAAGTHRHRKRGRSRSSDSRSQSRS1135GGGCATGATCAGAAGAATCATAGAAAGCATCATGGGAAGAAAAGAATGAAAAGTAAACGAGHDQKNHRKHHGKKRMKSKR1195TCCAGAAGCAGGGAAAGTAGCAGACCTAGAGGGAGAAGAGACAAAAAGAGATCAAGAACTSRSRESSRPRGRRDKKRSRT1255AGAGATAGCAGTTGGTCCAGAAGAAGCCAAACTCTGTCTCTAAGTAGTGAAAGCACAAGCRDSSWSRRSQTLSLSSESTS1315AGATCAAGGTCTCGTAGCAGTGATCATGGTAAAAGAAGATCACGGAGCAGAAATAGAGATRSRSRSSDHGKRRSRSRNRD1375CGTTATTATTTAAGAAATAATTATGGAAGCAGATACAAATGGGAGTATACTTATTACAGTRYYLRNNYGSRYKWEYTYYS(后续)1435AGAAACAAGGACAGGGATGGGTACGAATCATCTTACAGGAGGAGGACTCTGTCCAGAGCTRNKDRDGYESSYRRRTLSRA1495CATTATTCTAGACAGTCTTCAAGTCCAGAATTTAGAGTTCAGTCCTTTTCTGAAAGAACAHYSRQSSSPEFRVQSFSERT1555AATGCTAGGAAAAAAAATAATCACAGTGAGAGGAAGTATTACTACTATGAAAGGCACAGANARKKNNHSERKYYYYERHR1615TCAAGGAGCCTGTCTAGTAACAGATCAAGGACTGCATCTACCGGGACTGACCGGGTGAGASRSLSSNRSRTASTGTDRVR1675AATGAAAAGCCTGGAGGGAAACGAAAATACAAAACACGGCATTTGGAGGGTACTAACGAANEKPGGKRKYKTRHLEGTNE1735GTGGCTCAGCCATCTCGTGAATTTGCTTCTAAAGCAAAGGACAGTCATTACCAAAAATCTVAQPSREFASKAKDSHYQKS1795TCATCAAAATTGGATGGAAACTACAAAAATGAGAGTGATACCTTTTCAGACAGCCGATCASSKLDGNYKNESDTFSDSRS1855TCAGACAGAGAGACAAAACACAAAAGGAGAAAAAGGAAGACCCGGAGCCTAAGTGTAGAGSDRETKHKRRKRKTRSLSVE1915ATAGTTTATGAAGGAAAAGCTACTGATACAACTAAACACCATAAAAAGAAAAAGAAGAAAIVYEGKATDTTKHHKKKKKK1975CATAAGAAGAAGCATAAGAAACACCATGGAGATAATGCTTCACGTTCCCCAGTTGTAATTHKKKHKKHHGDNASRSPVVI2035ACCATTGACAGTGACAGTGATAAGGATTCTGAAGTAAAGGAGGATACAGAATGTGACAATTIDSDSDKDSEVKEDTECDN2095AGTGGTCCTCAAGACCCTCTACAAAATGAGTTTTTGGCTCCTTCCTTGGAACCATTTGAASGPQDPLQNEFLAPSLEPFE2155ACTAAAGATGTAGTTACAATAGAAGCTGAATTTGGTGTGCTGGACAAGGAATGTGATATTTKDVVTIEAEFGVLDKECDI2215GCCACACTTAGTAACAACTTGAATAATGCCAACAAAACTGTAGATAATATTCCACCTCTGATLSNNLNNANKTVDNIPPL2275GCAGCTTCAGTTGAACAAACTCTCGATGTAAGAGAAGAGAGCACCTTTGTTTCTGATTTGAASVEQTLDVREESTFVSDL2335GAGAACCAGCCCAGTAACATTGTGTCTCTTCAAACTGAGCCATCAAGGCAATTGCCATCGENQPSNIVSLQTEPSRQLPS2395CCACGGACATCATTAATGTCAGTATGTCTTGGTAGAGACTGTGATATGTCTTAAAACTGCPRTSLMSVCLGRDCDMS*2455CAAAGCATTTCATTGAGAATTATGATGTTATAAAAAGGAAAAAGGAAGAATGTCGTCTAC2515TGCAGTCTATTTAAAGATGACATTTGGTGAAAACTCTCTTCCTCCTTACAATATTTTAAA2575TGATTTTTTTTTTGGTGTTAATTTGTAAAAATCATTATTTGTTCAAAATGTATGTCCCAC2635CCTCAAAGATATGCACTTTTAAGTGAAGAAAATGATACTGCTAGCAGCTTATTTAAAACT2695TGGGGTCCTTTTTAAATAAGAAAAATTATATAAATTTTAGAAGTTATTTCATAAAGCCAT2755ACGGTATTGACATATTTTTAAGGTAGTCAATGAGTATTTTTGAATTTTTTTTTTTTGAGA2815GTTATTCTGGAAATGTGTTATAAGCTAGGAGAATCCCTTTGGACAGTCTTTATTTTTCTT2875CTTAAAAATTTATATGATTCAAAACCATTTCTTCAGGTTAAATTGAGGCATTTTAATCTG2935CACAGTTTATCTTCTGCCAAAATAAAAATTTACTATTTCCTTTATATACTTGTTTATCTG2995GACTGCCAGTAAAAC
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