[发明专利]GLP-1R激活剂的分子改构及其二聚体在治疗代谢病中的应用

权利要求书

1.一种胰高血糖素样肽-1受体(GLP-1R)激活剂类似肽，其特征在于，所述类似肽的具体序列为以下任意一种：

(1)(HN₂)HGEGTFTSDLCK[N-ε-(L-γ-Glu-N-α-18CFA)]QMEEEAVRLFIEWLKNGGPSSGAPPPS(NH₂)；

(2)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-18CFA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(3)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-18CFDA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(4)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-20CFA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(5)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(6)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-L-γ-Glu-N-α-18CFDA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(7)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-L-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPPS(NH₂)；

(8)(HN₂)H-αAib-EGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-L-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPS(NH₂)；

(9)(HN₂)H-αAib-EGTFTSDLCK[N-ε-(2×AEEAC-L-γ-Glu-N-α-20CFDA)]QMEEEAVRLFIEWLKNGGPSSGAPPPS(NH₂)；

(10)(HN₂)Hα-Aib-EGTFTSDLCKQMEEEAVRLFIEWLK[N-ε-(2×AEEAC-L-γ-Glu-N-α-20CFDA)]NGGPSSGAPPPS(NH₂)；

(11)(HN₂)HGEGTFTSDLCKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(12)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-20CFA)]LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(13)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(14)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-γ-Glu-N-α-18CFDA)LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(15)(HN₂)HGEGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(16)(HN₂)H-αAib-EGTFTSDLCKQMEEEAVK[N-ε-(L-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)；

(17)(HN₂)H-αAib-EGTFTSDLCKQMEEEAVK[N-ε-(2×AEEAC-γ-Glu-N-α-20CFDA)]LFIEWLKNGGPSSGAPPSKKKKKK(NH₂)。