[发明专利]一类非洲爪蟾胰高血糖素样肽-1类似物及其应用

权利要求书

1.非洲爪蟾胰高血糖素样肽-1类似物，其特征在于，其序列为：

His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Xaa₂-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Xaa₃-Gly-Xaa₄-Xaa₅；

其中：

Xaa₁:Ala，Gly或Aib；

Xaa₂:Lys(fatty acid analog)或Lys；

Xaa₃:Lys(fatty acid analog)或Lys；

Xaa₄:Lys(fatty acid analog)或Lys；

Xaa₅:Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-OH，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH₂，Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-OH，-OH或-NH₂；

且所述序列不是His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-NH₂,His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-OH，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-OH，His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-NH₂或His-Xaa₁-Glu-Gly-Thr-Tyr-Thr-Asn-Asp-Val-Thr-Glu-Tyr-Leu-Glu-Glu-Glu-Ala-Ala-Lys-Glu-Phe-Ile-Glu-Trp-Leu-Ile-Lys-Gly-Lys-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys-OH。

2.根据权利要求1所述非洲爪蟾胰高血糖素样肽-1类似物，其特征在于，所述Lys(fatty acid analog)是

3.根据权利要求2所述非洲爪蟾胰高血糖素样肽-1类似物，其特征在于，所述n是12～20。