[发明专利]用于同时检测HIV-1、HIV-2、HTLV-Ⅰ和HTLV-Ⅱ抗体的免疫检测法无效
申请号: | 92108855.8 | 申请日: | 1992-07-29 |
公开(公告)号: | CN1070484A | 公开(公告)日: | 1993-03-31 |
发明(设计)人: | M·拉克劳西;R·J·德怀尔;M·兹莱 | 申请(专利权)人: | 生物化学药物有限公司 |
主分类号: | G01N33/53 | 分类号: | G01N33/53 |
代理公司: | 中国国际贸易促进委员会专利代理部 | 代理人: | 黄革生 |
地址: | 加拿大*** | 国省代码: | 暂无信息 |
权利要求书: | 查看更多 | 说明书: | 查看更多 |
摘要: | |||
搜索关键词: | 用于 同时 检测 hiv htlv 抗体 免疫 | ||
1、用于同时检测抗HIV-1、HIV-2、HTLV-Ⅰ和HTLV-Ⅱ抗体的免疫检测药盒,它包括四组肽中每一组的至少一种肽,且被偶联到固相载体上,这四组肽具有通式a-X-b、a-Y-b、a-Z-b和a-W-b,其中
X选自
Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu
Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr
Ala Val Pro Trp Asn Ala Ser (BCH-87C)
Lys Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu
Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr
Ala Val Pro Trp Asn Ala Ser (BCH-87ck)
Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg
Arg Val Val Gln Arg Glu Lys Arg (BCH-132)
Lys Lys Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln
Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr
Thr Ala Val Pro Trp Asn Ala Ser (BCH-266)
Lys Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu
Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr
Ala Val Pro Trp Asn Ala Ser Gly Lys Leu Ile (BCH-408)
Lys Lys Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln
Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr
Thr Ala Val Pro Trp Asn Ala Ser Gly Lys Leu Ile (BCH-408k)
及其类似物;
Y选自
Arg Val Thr Ala Ile Glu Lys Tyr Leu Gln Asp Gln Ala Arg
Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr
Thr Val Pro Trp Val Asn Asp Ser (BCH-202c)
Lys Val Thr Ala Ile Glu Lys Tyr Leu Gln Asp Gln Ala Arg
Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr
Thr Val Pro Trp Val Asn Asp Ser (BCH-202ck)
Lys Lys Val Thr Ala Ile Glu Lys Tyr Leu Gln Asp Gln Ala
Arg Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His
Thr Thr Val Pro Trp Val Asn Asp Ser (BCH-265)
Lys Val Thr Ala Ile Glu Lys Tys Leu Gln Asp Gln Ala Arg
Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr
Thr Val Pro Trp Val Asn Asp Ser Ala Phe Arg Gln Val (BCH-417)
Lys Val Thr Ala Ile Glu Lys Tyr Leu Gln Asp Gln Ala Arg
Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr
Thr Val Pro Trp Val Asn Asp Ser Gly Lys His Ile (BCH-422)
及其类似物;
Z选自
Pro His Ser Asn Leu Asp His Ile Leu Glu Pro Ser Ile Pro
Trp Lys Ser Lys Pro Tyr Val Glu Pro Thr Ala Pro Gln Val
Leu (BCH-234)
Ala Ile Val Ser Ser Pro Ser His Asn Ser Leu Ile Leu Pro
Pro Phe Ser Leu Ser Pro Val Pro Thr Leu
Gly Ser Arg (BCH-416)
及其类似物;
W选自
Leu Val His Asp Ser Asp Leu Glu His Val Leu Thr Pro Ser
Thr Ser Trp Thr Thr Lys Ile Leu (BCH-219)
Thr Ser Glu Pro Thr Gln Pro Pro Pro Thr Ser Pro Pro Leu
Leu Val His Asp Ser Asp Leu Glu His Val Leu (BCH-456)
Thr Ser Glu Pro Thr Gln Pro Pro Pro Thr Ser Pro Pro Leu
Val His Asp Ser Asp Leu Glu His Val Leu (BCH-486)
及其类似物;
a为氨基末端,1-8个氨基酸或能够有效促进肽偶联或改进肽免疫原性或抗原性的取代基;
b为羧基末端,1-8个氨基酸或能够有效促进肽偶联或改进肽免疫原性或抗原性的取代基。
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